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L121

Levallorphan tartrate salt

Name: Levallorphan tartrate salt
Brand: SIGMA

≥98% (HPLC), powder

Synonym(s):

17-(2-Propenyl)morphinan-3-ol tartrate

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₂₅NO · C₄H₆O₆

CAS Number:

71-82-9

Molecular Weight:

433.49

NACRES:

NA.77

PubChem Substance ID:

24278815

UNSPSC Code:

12352200

EC Number:

200-767-3

MDL number:

MFCD00210203

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]22/D −35°, c = 0.38 in H₂O(lit.)

color

white to beige

solubility

H₂O: 5 mg/mL, clear

originator

Roche

SMILES string

O[C@H]([C@@H](O)C(O)=O)C(O)=O.[H][C@@]12CCCC[C@@]13CCN(CC=C)[C@@H]2Cc4ccc(O)cc34

InChI

1S/C19H25NO.C4H6O6/c1-2-10-20-11-9-19-8-4-3-5-16(19)18(20)12-14-6-7-15(21)13-17(14)19;5-1(3(7)8)2(6)4(9)10/h2,6-7,13,16,18,21H,1,3-5,8-12H2;1-2,5-6H,(H,7,8)(H,9,10)/t16-,18+,19+;1-,2-/m01/s1

InChI key

FWMLYVACGDQRFU-ZTMWJVNESA-N

Gene Information

human ... OPRD1(4985), OPRM1(4988)

Biochem/physiol Actions

Partial agonist (antagonist) at μ and δ opioid receptors.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Disclaimer

Photosensitive

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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mu-Opioid receptor-stimulated guanosine-5'-O-(gamma-thio)-triphosphate binding in rat thalamus and cultured cell lines: signal transduction mechanisms underlying agonist efficacy.

D E Selley et al.

Molecular pharmacology, 51(1), 87-96 (1997-01-01)

G protein activation by different mu-selective opioid agonists was examined in rat thalamus, SK-N-SH cells, and mu-opioid receptor-transfected mMOR-CHO cells using agonist-stimulated guanosine-5'-O-(gamma-thio)-triphosphate ([35S]GTP gamma S) binding to membranes in the presence of excess GDP. [D-Ala2, N-MePhe4, Gly5-ol]Enkephalin (DAMGO) was

Physical and Pharmacokinetic Characterizations of trans-Resveratrol (t-Rev) Encapsulated with Self-Assembling Lecithin-based Mixed Polymeric Micelles (saLMPMs).

Tzu-Pin Li et al.

Scientific reports, 7(1), 10674-10674 (2017-09-08)

This study involved physical and pharmacokinetic characterizations of trans-resveratrol (t-Rev)-loaded saLMPMs which attempted to improve t-Rev's pharmacokinetic profiles and bioavailability resolving hurdles limiting its potential health benefits. The optimal formulation consisted of t-Rev, lecithin, and Pluronic

Development and characterization of self-assembling lecithin-based mixed polymeric micelles containing quercetin in cancer treatment and an in vivo pharmacokinetic study.

Ling-Chun Chen et al.

International journal of nanomedicine, 11, 1557-1566 (2016-05-05)

Quercetin (Que) is known to have biological benefits including an anticancer effect, but low water solubility limits its clinical application. The aim of this study was to develop a lecithin-based mixed polymeric micelle (LMPM) delivery system to improve the solubility

Physical characterization and in vivo pharmacokinetic study of self-assembling amphotericin B-loaded lecithin-based mixed polymeric micelles.

Ying-Chen Chen et al.

International journal of nanomedicine, 10, 7265-7274 (2015-12-15)

To alleviate the inherent problems of amphotericin B (AmB), such as poor water solubility and nephrotoxicity, a novel self-assembling mixed polymeric micelle delivery system based on lecithin and combined with amphiphilic polymers, Pluronic(®), Kolliphor(®), d-alpha tocopheryl polyethylene glycol succinate, and

Monitoring of the Zeta Potential of Human Cells upon Reduction in Their Viability and Interaction with Polymers.

O V Bondar et al.

Acta naturae, 4(1), 78-81 (2012-06-19)

The dynamic light scattering (DLS) technique was applied in order to assess the zeta potential of the plasma membrane of human cells. At pH 7.4, the cell zeta potential for different types of cells showed variations over a wide range

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Global Trade Item Number

SKU	GTIN
L121-5MG	04061833949238

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