L131
L-745,870 hydrochloride
Synonym(s):
3-[[4-(4-Chlorophenyl)piperazin-1-yl]methyl]-1H-pyrrolo[2,3-b]pyridine hydrochloride
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About This Item
Empirical Formula (Hill Notation):
C18H19ClN4 · HCl
CAS Number:
Molecular Weight:
363.28
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
form
solid
Quality Level
color
white
solubility
H2O: 0.2 mg/mL
ethanol: 1.4 mg/mL
0.1 M HCl: 5.5 mg/mL
SMILES string
Cl.Clc1ccc(cc1)N2CCN(CC2)Cc3c[nH]c4ncccc34
InChI
1S/C18H19ClN4.ClH/c19-15-3-5-16(6-4-15)23-10-8-22(9-11-23)13-14-12-21-18-17(14)2-1-7-20-18;/h1-7,12H,8-11,13H2,(H,20,21);1H
InChI key
GFFJYISJZJIKAF-UHFFFAOYSA-N
Gene Information
human ... DRD4(1815)
Biochem/physiol Actions
Selective D4 dopamine receptor antagonist.
Features and Benefits
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Legal Information
Manufactured and sold under license from Merck & Co., Inc., Kenilworth, NJ, U.S. for use solely for preclinical researchy purposes (i.e., not for the administration to or other use in humans).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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S Patel et al.
The Journal of pharmacology and experimental therapeutics, 283(2), 636-647 (1997-11-14)
L-745,870,(3-([4-(4-chlorophenyl)piperazin-1-yl]methyl)-1H- pyrollo[2,3-b] pyridine, was identified as a selective dopamine D4 receptor antagonist with excellent oral bioavailability and brain penetration. L-745,870 displaced specific binding of 0.2 nM [3H] spiperone to cloned human dopamine D4 receptors with a binding affinity (Ki) of
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