L2145
L -Leucine-7-amido-4-methylcoumarin hydrochloride
fluorogenic, ≥98% (TLC), powder
Synonym(s):
H-L-Leu-AMC HCl
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About This Item
Empirical Formula (Hill Notation):
C16H20N2O3 · HCl
CAS Number:
Molecular Weight:
324.80
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
MDL number:
Product Name
assay
≥98% (TLC)
Quality Segment
form
powder
solubility
methanol: 50 mg/mL, clear, colorless to faintly yellow
fluorescence
λex 327 nm; λem 349 nm (pH 8.0), λex 380 nm; λem 440 nm (Reaction product)
storage temp.
−20°C
SMILES string
Cl.CC(C)C[C@H](N)C(=O)Nc1ccc2C(C)=CC(=O)Oc2c1
InChI
1S/C16H20N2O3.ClH/c1-9(2)6-13(17)16(20)18-11-4-5-12-10(3)7-15(19)21-14(12)8-11;/h4-5,7-9,13H,6,17H2,1-3H3,(H,18,20);1H/t13-;/m0./s1
InChI key
VCRXITKKWBOQRZ-ZOWNYOTGSA-N
General description
L-Leucine-7-amido-4-methylcoumarin hydrochloride (Leu-AMC) is a fluorogenic peptidyl substrate for leucine aminopeptidase, an extracellular enzyme found abundantly in natural aquatic systems. This enzyme is one of the various enzymes used by bacteria for protein hydrolysis.
Application
L-Leucine-7-amido-4-methylcoumarin hydrochloride has been used:
- as a substrate in fluorescence-based soil assays
- to determine leucine aminopeptidase activity of both Plasmodium falciparum M1 (PfA-M1) and PfA-M17 enzymes
L-Leucine-7-amido-4-methylcoumarin hydrochloride (Leu-AMC) as a substrate analog to determine leucine aminopeptidase activity
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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