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L2540

L-368,899

Name: L-<SC>368,899</SC>
Brand: SIGMA

≥98% (HPLC), OTR antagonist, powder

Synonym(s):

1-((7,7-Dimethyl-2(S)-(2(S)-amino-4-(methylsulfonyl)butyramido)bicyclo[2,2,1]heptan-1(S)-yl)methylsulfonyl)-4-(2-methylphenyl)piperazine hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₂₆H₄₂O₅N₄S₂ · HCl

CAS Number:

160312-62-9

Molecular Weight:

591.23

UNSPSC Code:

51111800

PubChem Substance ID:

24278804

NACRES:

NA.77

MDL number:

MFCD09753328

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Product Name

L-368,899, ≥98% (HPLC), powder

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white

solubility

H₂O: soluble 20 mg/mL

originator

Merck & Co., Inc., Kenilworth, NJ, U.S.

storage temp.

−20°C

SMILES string

Cl.Cc1ccccc1N2CCN(CC2)S(=O)(=O)C[C@]34CC[C@H](C[C@@H]3NC(=O)[C@@H](N)CCS(C)(=O)=O)C4(C)C

InChI

1S/C26H42N4O5S2.ClH/c1-19-7-5-6-8-22(19)29-12-14-30(15-13-29)37(34,35)18-26-11-9-20(25(26,2)3)17-23(26)28-24(31)21(27)10-16-36(4,32)33;/h5-8,20-21,23H,9-18,27H2,1-4H3,(H,28,31);1H/t20-,21+,23+,26-;/m1./s1

InChI key

GIUFQWFJHXXXEQ-SWJTYIIKSA-N

Gene Information

human ... OXTR(5021)

Related Categories

Bioactive Small Molecules

Biochem/physiol Actions

L-368,899 is a non-peptide oxytocin receptor (OTR) antagonist.

Features and Benefits

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000532866

0000258792

0000194676

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Impaired approach to novelty and striatal alterations in the oxytocin receptor deficient mouse model of autism.

Marianna Leonzino et al.

Hormones and behavior, 114, 104543-104543 (2019-06-21)

Long-standing studies established a role for the oxytocin system in social behavior, social reward, pair bonding and affiliation. Oxytocin receptors, implicated in pathological conditions affecting the social sphere such as autism spectrum disorders, can also modulate cognitive processes, an aspect

Oxytocin Receptors on Calvarial Periosteal Innervation: Therapeutic Target for Post-Traumatic Headache?

Vimala N Bharadwaj et al.

Pharmaceutics, 16(6) (2024-06-27)

Following a mild traumatic brain injury (mTBI), the most prevalent and profoundly debilitating occurrence is the emergence of an acute and persistent post-traumatic headache (PTH), for which there are presently no approved treatments. A crucial gap in knowledge exists regarding

Commensal microbe-derived propionic acid mediates juvenile social isolation-induced social deficits and anxiety-like behaviors.

Ling Huang et al.

Brain research bulletin, 166, 161-171 (2020-12-07)

Social experiences during early life are thought to be critical for proper social and emotional development. Conversely, social insults during development causes long-lasting behavioral abnormalities later in life. However, how juvenile social deprivation influences social and emotional behaviors remains poorly

Global Trade Item Number

SKU	GTIN
L2540-5MG	04061833033579

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