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L3169

Sigma-Aldrich

LP 12 hydrochloride hydrate

≥98% (HPLC), solid

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Synonym(s):
4-(2-Diphenyl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)-1- piperazinehexanamide hydrochloride
Empirical Formula (Hill Notation):
C32H39N3O·HCl · xH2O
Molecular Weight:
518.13 (anhydrous basis)
MDL number:
MFCD11114387
PubChem Substance ID:
329817403
NACRES:
NA.77

Quality Level

100

Assay

≥98% (HPLC)

form

solid

color

off-white

solubility

DMSO: >5 mg/mL
H2O: 6 mg/mL

storage temp.

−20°C

SMILES string

O.Cl.O=C(CCCCCN1CCN(CC1)c2ccccc2-c3ccccc3)NC4CCCc5ccccc45

InChI

1S/C32H39N3O.ClH.H2O/c36-32(33-30-18-11-15-26-14-6-7-16-28(26)30)20-5-2-10-21-34-22-24-35(25-23-34)31-19-9-8-17-29(31)27-12-3-1-4-13-27;;/h1,3-4,6-9,12-14,16-17,19,30H,2,5,10-11,15,18,20-25H2,(H,33,36);1H;1H2

InChI key

VOKWUIAIZYWMDR-UHFFFAOYSA-N

Biochem/physiol Actions

LP 12 dihydrochloride is a 5-HT7 receptor agonist displaying selectivity over D2, 5-HT1A and 5-HT2A receptors (Ki values are 0.13, 224, 60.9 and 1464 nM, respectively. It also displays selectivity over D2, 1723; over 5-HT1A, 468; over 5-HT2A, 11261; and high potency. Sigma has added LP 44 (L9793) which shows significantly lower D2 selectivity (7.3 nM/0.22 nM for 33-fold), lower selectivity over 5-HT1A, 240; and over 5-HT2A, 1482. LP 12 and LP 44 seem to share a common intermediate.

comparable product

Product No.
Description
Pricing

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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