L3398
Luteinizing hormone releasing hormone Fragment 7-10 dihydrochloride
≥97% (HPLC)
Synonym(s):
Leu-Arg-Pro-Gly-NH2, LH-RH Fragment 7-10 dihydrochloride
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About This Item
Empirical Formula (Hill Notation):
C19H36N8O4 · 2HCl
CAS Number:
Molecular Weight:
513.46
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
Assay:
≥97% (HPLC)
assay
≥97% (HPLC)
storage temp.
−20°C
SMILES string
Cl.CC(C)CC(N)C(=O)NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)NCC(N)=O
InChI
1S/C19H36N8O4.ClH/c1-11(2)9-12(20)16(29)26-13(5-3-7-24-19(22)23)18(31)27-8-4-6-14(27)17(30)25-10-15(21)28;/h11-14H,3-10,20H2,1-2H3,(H2,21,28)(H,25,30)(H,26,29)(H4,22,23,24);1H
InChI key
JKIOGUIXJNHXTH-UHFFFAOYSA-N
signalword
Danger
hcodes
pcodes
Hazard Classifications
Repr. 1B
Storage Class
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
Regulatory Information
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Sudhir N Umathe et al.
Behavioural pharmacology, 19(4), 308-316 (2008-07-16)
The correlation between neuronal mechanism of anxiety and neuroanatomic expression/neuromodulatory role of gonadotropin-releasing hormone (GnRH), points to a role of GnRH in the modulation of anxiety. Therefore, we investigated the influence of GnRH agonists and antagonist on the anxiety-like behavior
Non-peptidic GnRH receptor antagonists.
Armer RE, Smelt KH.
Current Medicinal Chemistry, 11, 33017-33028 (2004)
R P Millar et al.
British medical bulletin, 56(3), 761-772 (2001-03-20)
Gonadotropin-releasing hormone (GnRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) which is produced from a precursor polypeptide in hypothalamic neurons and secreted in a pulsatile fashion to stimulate the secretion of LH and FSH via its interaction with a cognate receptor on gonadotropes.