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Merck
CN

L3398

Luteinizing hormone releasing hormone Fragment 7-10 dihydrochloride

≥97% (HPLC)

Synonym(s):

LH-RH Fragment 7-10 dihydrochloride, Leu-Arg-Pro-Gly-NH2

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About This Item

Empirical Formula (Hill Notation):
C19H36N8O4 · 2HCl
CAS Number:
75690-75-4
Molecular Weight:
513.46
MDL number:
MFCD00133509
UNSPSC Code:
12352200
PubChem Substance ID:
24896340
Assay:
≥97% (HPLC)

Key Documents

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Assay

≥97% (HPLC)

storage temp.

−20°C

SMILES string

Cl.CC(C)CC(N)C(=O)NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)NCC(N)=O

InChI

1S/C19H36N8O4.ClH/c1-11(2)9-12(20)16(29)26-13(5-3-7-24-19(22)23)18(31)27-8-4-6-14(27)17(30)25-10-15(21)28;/h11-14H,3-10,20H2,1-2H3,(H2,21,28)(H,25,30)(H,26,29)(H4,22,23,24);1H

InChI key

JKIOGUIXJNHXTH-UHFFFAOYSA-N

Pictograms

Health hazard
GHS08

Signal Word

Danger

Hazard Statements

H360

Precautionary Statements

P201 - P308 + P313

Hazard Classifications

Repr. 1B

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

新产品
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Certificates of Analysis (COA)

Lot/Batch Number
070H0225
070H02251
070H02253
070H02252

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Sudhir N Umathe et al.
Behavioural pharmacology, 19(4), 308-316 (2008-07-16)
The correlation between neuronal mechanism of anxiety and neuroanatomic expression/neuromodulatory role of gonadotropin-releasing hormone (GnRH), points to a role of GnRH in the modulation of anxiety. Therefore, we investigated the influence of GnRH agonists and antagonist on the anxiety-like behavior
R P Millar et al.
British medical bulletin, 56(3), 761-772 (2001-03-20)
Gonadotropin-releasing hormone (GnRH) is a decapeptide (pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly.NH2) which is produced from a precursor polypeptide in hypothalamic neurons and secreted in a pulsatile fashion to stimulate the secretion of LH and FSH via its interaction with a cognate receptor on gonadotropes.
Non-peptidic GnRH receptor antagonists.
Armer RE, Smelt KH.
Current Medicinal Chemistry, 11, 33017-33028 (2004)
V Singh
Biochemistry and cell biology = Biochimie et biologie cellulaire, 64(12), 1372-1377 (1986-12-01)
Immunochemical studies on monoclonal and conventional anti-LHRH antibodies have been reported. The association constants (Ka) were in the order of 10(9)-10(10) L/mol when calculated from Scatchard and Steward-Petty plots. Heterogeneity indices (a) calculated from Sips plot were nearly 1.0, indicating

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