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Merck
CN

L4646

Lipids Cholesterol Rich from adult bovine serum

liquid, sterile-filtered, BioReagent, suitable for cell culture, suitable for insect cell culture

Synonym(s):

Bovine Serum Lipids, Cholesterol Rich Lipids, Lipids from Bovine

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About This Item

NACRES:
NA.75
UNSPSC Code:
12352211
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sterility

sterile-filtered

Quality Level

product line

BioReagent

form

liquid

composition

Cholesterol, 9.0-11.0 g/L , Protein, 15.0-25.0 g/L

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable

impurities

Adventitious viral agents, none detected (9 CFR; 113.53), IgG, none detected (RID), Microbial content, none detected (USP XXII), Mycoplasma, none detected (Barile method), ≤6.0 EU/mg cholesterol endotoxin

storage temp.

2-8°C

General description

Cholesterol is a lipid molecule, found integrated to the cell membrane.

Application

Lipids Cholesterol Rich from adult bovine serum has been used as one of the lipid component to generate erythroblasts ex vivo. It has also been used as a standard to determine muscle cholesterol level, spectrophotometrically.

Biochem/physiol Actions

Cholesterol significantly affects the property of phospholipid membrane such as fluidity and membrane protein function. It exhibits a condensing effect towards phospholipids. Cholesterol-phospholipid interaction influences physiological properties of a lipid bilayer. Cholesterol serves as a precursor of bile acids, steroid hormones and vitamin D. Uncontrolled level of plasma cholesterol might lead to the risk of cardiovascular disorder.

Other Notes

Aqueous lipoprotein solution


Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

监管及禁止进口产品

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Effect of cholesterol on the structure of a phospholipid bilayer
de Meyer F and Smit B
Proceedings of the National Academy of Sciences of the USA, 106(10), 3654-3658 (2009)
The condensing effect of cholesterol in lipid bilayers
Hung WC, et al.
Biophysical Journal, 92(11), 3960-3967 (2007)
Paoletti R. and Kritchevsky D.
Advances in Lipid Research, 8, 1-1 (2014)



Global Trade Item Number

SKUGTIN
L4646-100ML04061833957653
L4646-20ML04061833957660