L4912
Leptin Receptor/Fc Chimera from mouse
≥97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture
Synonym(s):
B219
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About This Item
UNSPSC Code:
51111800
MDL number:
Form:
lyophilized powder
Assay:
≥97% (SDS-PAGE)
Recombinant:
expressed in NSO cells
recombinant
expressed in NSO cells
assay
≥97% (SDS-PAGE)
form
lyophilized powder
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Lepr(16847)
Biochem/physiol Actions
Leptin receptor is important for regulating appetite and energy expenditure. The neuroendocrine hormone, leptin, works through leptin receptor. In humans and mice, problems in expression of leptin or leptin receptor are associated with obesity.
Leptin receptor (OB-R) is a single membrane-spanning receptor most related to the gp-130 signal-transducing component of the IL-6 receptor, the G-CSF receptor and the LIF receptor. OB-R, also known as B219, is expressed in the yolk sac, early fetal liver, enriched hematopoitic stem cells and in a variety of lymphohematopoietic cell lines. OB-R is also expressed at high levels in adult reproductive organs. OB-RL action in hepatic cells may be equivalent to that of IL-6 receptor. Leptin does not play a specific role in muting insulin action on hepatoma cells and may not contribute to the diabetic symptoms associated with obesity.
Physical form
Lyophilized from 20 mM Tris containing 5 mg of bovine serum albumin per 100 μg leptin receptor.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Related Content
Melody L Allensworth-James et al.
Endocrinology, 156(9), 3253-3264 (2015-07-15)
Leptin receptor (LEPR) signaling controls appetite and energy expenditure. Somatotrope-specific deletion of the LEPRb signaling isoform causes GH deficiency and obesity. The present study selectively ablated Lepr exon 1 in somatotropes, which removes the signal peptide, causing the loss of
Jayasree Sreenivasan et al.
Immunology, 146(1), 122-129 (2015-06-11)
Leptin is an adipokine that regulates metabolism and plays an important role as a neuroendocrine hormone. Leptin mediates these functions via the leptin receptor, and deficiency in either leptin or its receptor leads to obesity in humans and mice. Leptin
Global Trade Item Number
| SKU | GTIN |
|---|---|
| L4912-.1MG | 04061832820767 |