L4920
Luotonin E
≥98%
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About This Item
Linear Formula:
C19H13N3O2
CAS Number:
Molecular Weight:
315.33
NACRES:
NA.77
UNSPSC Code:
12352202
biological source
synthetic (organic)
assay
≥98%
form
solid
solubility
chloroform/methanol (4:1): 4 mg/mL, clear to slightly hazy, colorless to yellow
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... TOP1(7150)
General description
Luotonin E is a heteroaromatic pyrroloquinazolinoquinoline alkaloid that, along with Luotonin A and B, was originally isolated from the Chinese medicinal plant Paganum nigellastrum. Luotonin compounds have antitumor activity and demonstrate cytotoxicity and inhibitory activity against human topoisomerase. For use as a topoisomerase inhibitor, a starting concentration of 25 μM is suggested. It is suggested that a dose-response curve be performed to find the inhibitor concentration most suitable for the intended assay.
Biochem/physiol Actions
Luotonin E exhibited strong cytotoxic effects specifically on human leukemia P-388 cells.
Preparation Note
Solubility is tested at 4 mg/mL in 4:1 solution of choloform and methanol. Solubility of luotonins in DMSO has been reported.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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