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L5420

Lumefantrine

Name: Lumefantrine
Brand: SIGMA

Synonym(s):

(9Z)-2,7-Dichloro-9-[(4-chlorophenyl)methylene]-α-[(dibutylamino)methyl]-9H-fluorene-4-methanol, Benflumetol, CPG-56695

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About This Item

Empirical Formula (Hill Notation):

C₃₀H₃₂Cl₃NO

CAS Number:

82186-77-4

Molecular Weight:

528.94

NACRES:

NA.77

PubChem Substance ID:

329817625

UNSPSC Code:

12352200

MDL number:

MFCD05662268

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Properties

assay

≥98% (HPLC)

Quality Level

100

form

powder

color

yellow

solubility

DMSO: 2 mg/mL, clear (warmed)

originator

Novartis

storage temp.

room temp

SMILES string

CCCCN(CCCC)CC(O)c1cc(Cl)cc2C(=C/c3ccc(Cl)cc3)\c4cc(Cl)ccc4-c12

InChI

1S/C30H32Cl3NO/c1-3-5-13-34(14-6-4-2)19-29(35)28-18-23(33)17-27-25(15-20-7-9-21(31)10-8-20)26-16-22(32)11-12-24(26)30(27)28/h7-12,15-18,29,35H,3-6,13-14,19H2,1-2H3/b25-15-

InChI key

DYLGFOYVTXJFJP-MYYYXRDXSA-N

Description

General description

Lumefantrine, also known as benflumetol is an aryl-amino alcohol. It is a member of the group of arylamine alcohols like quinine, mefloquine and halofantrine.

Application

Lumefantrine has been used:
to study its effect on ex-vivo Plasmodium falciparum sensitivity using the tritiated hypoxanthine-based assay
as a standard in the quantification of combined tablet formulation using HPTLC
as a drug molecule in in vitro growth inhibition assay for in vitro B. caballi growth inhibition studies

Biochem/physiol Actions

Lumefantrine is is an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

0000489491

0000470524

0000305969

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Articles

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

Evaluating the effect of innovative motivation and supervision approaches on community health worker performance and retention in Uganda and Mozambique: study protocol for a randomised controlled trial.

Karin Källander et al.

Trials, 16, 157-157 (2015-04-16)

If trained, equipped and utilised, community health workers (CHWs) delivering integrated community case management for sick children can potentially reduce child deaths by 60%. However, it is essential to maintain CHW motivation and performance. The inSCALE project aims to evaluate

Use of a model procedure for transfer of Minilab qualitative screening TLC methods for lumefantrine and artemether in a combined tablet formulation to individual and simultaneous quantitative HPTLC-densitometry methods

Nguyen M and Sherma J

Malaria Journal (2013)

Lumefantrine and o-choline-Parasite metabolism specific drug molecules inhibited in vitro growth of Theileria equi and Babesia caballi in MASP culture system

Maji C, et al.

Ticks and Tick-Borne Diseases, 10(3), 568-574 (2019)

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Global Trade Item Number

SKU	GTIN
L5420-5MG	04061833958124
L5420-25MG	04061833958117