L6010
α-Lactalbumin from bovine milk
Type III, calcium depleted, ≥85% (PAGE), lyophilized powder
Synonym(s):
Bos d 4, Lactose synthase B protein, alpha-lactalbumin
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
About This Item
Biological source:
bovine milk
Assay:
≥85% (PAGE)
Form:
lyophilized powder
Technique(s):
indirect ELISA: suitable
Impurities:
cation traces, tested
Concentration:
≥85 % protein
biological source
bovine milk
Quality Level
type
Type III
assay
≥85% (PAGE)
form
lyophilized powder
quality
calcium depleted
mol wt
14,178 Da by calculation
concentration
≥85 % protein
technique(s)
indirect ELISA: suitable
impurities
cation traces, tested
solubility
H2O: soluble 10 mg/mL, clear to slightly hazy, colorless to faintly yellow
cation traces
Ca: ≤0.3 mol/mol
UniProt accession no.
storage temp.
−20°C
Gene Information
cow ... LALBA(281894)
Looking for similar products? Visit Product Comparison Guide
General description
may contain traces of (NH4)2SO4 and sodium phosphateL6010
Application
α-Lactalbumin from bovine milk has been used:
- in indirect enzyme-linked immunosorbent assay (ELISA) and competitive ELISA methods
- in binding of Hsp90 and HSJ1b analysis
- to inhibit the lysozyme CAP-RAST assay
Biochem/physiol Actions
α-Lactalbumin is the cheif protein in human milk. It consists of a single polypeptide chain with 8 cysteines which form disulfide bridges. α-Lactalbumin binds several metal ions, including calcium, which is thought to play a role in the regeneration of native α-lactalbumin from the reduced, denatured form. α-Lactalbumin also has a distinct zinc binding site that is thought to play a role in the binding of the lactose synthase complex.The mature protein consists of 123 amino acid residues (14 kD), and it has a three-dimensional structure with 1.7 Angstrom resolution, demonstrating four α-helices and a triple stranded antiparallel β-sheet.
Alters the substrate specificity of galactosyltransferase to increase the rate of lactose formation; the complex of galactosyltransferase and α-lactalbumin is called lactose synthase.
Alters the substrate specificity of galactosyltransferase to increase the rate of lactose formation; the complex of galactosyltransferase and α-lactalbumin is called lactose synthase. Site-directed mutagenesis of Asp87 or Asp88 to Ala completely abolishes the strong calcium binding affinity and reduces the stimulation of lactose synthase to <3.5% of the maximal rate.
Analysis Note
May contain traces of (NH4)2SO4 and sodium phosphate.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
低风险生物材料
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Ozgür Tarhan et al.
The Journal of dairy research, 81(1), 98-106 (2013-12-20)
Alpha-lactalbumin (α-la) is one of the major proteins in whey. When partially hydrolysed with Bacillus licheniformis protease, it produces nanotubular structures in the presence of calcium ions by a self-assembly process. This study presents investigation of α-la protein structure during
Prevalence of lysozyme sensitization in an egg-allergic population
Fremont S, et al.
Allergy, 52(2), 224-228 (1997)
T Schnaider et al.
Life sciences, 67(12), 1455-1465 (2000-09-13)
The 90 kDa heat shock protein (Hsp90) is a major cytoplasmic molecular chaperone associating with numerous other proteins. Both genetic and in vitro refolding experiments using reticulocyte lysate have suggested a functional interaction of Hsp90 with yeast human homologues of
Melanie Jannaway et al.
Frontiers in physiology, 12, 687563-687563 (2021-10-09)
Lymphatic vascular permeability prevents lymph leakage that is associated with lymphedema, lymphatic malformations, obesity, and inflammation. However, the molecular control of lymphatic permeability remains poorly understood. Recent studies have suggested that adherens junctions and vesicle transport may be involved in
Effect of conjugation of cow milk whey protein with polyethylene glycol on changes in their immunoreactive and allergic properties
Wroblewska B and Jedrychowski L
Food and agricultural immunology, 14(2), 155-162 (2002)
Related Content
Product Information Sheet
Global Trade Item Number
| SKU | GTIN |
|---|---|
| L6010-500MG | 04061833263501 |
| L6010-100MG | 04061833958568 |
| L6010-1G | 04061833958575 |
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service