L6010
α-Lactalbumin from bovine milk
Type III, calcium depleted, ≥85% (PAGE), lyophilized powder
Synonym(s):
Bos d 4, Lactose synthase B protein, alpha-lactalbumin
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About This Item
Biological source:
bovine milk
Assay:
≥85% (PAGE)
Form:
lyophilized powder
Technique(s):
indirect ELISA: suitable
Impurities:
cation traces, tested
Concentration:
≥85 % protein
biological source
bovine milk
Quality Segment
type
Type III
assay
≥85% (PAGE)
form
lyophilized powder
quality
calcium depleted
mol wt
14,178 Da by calculation
concentration
≥85 % protein
technique(s)
indirect ELISA: suitable
impurities
cation traces, tested
solubility
H2O: soluble 10 mg/mL, clear to slightly hazy, colorless to faintly yellow
cation traces
Ca: ≤0.3 mol/mol
UniProt accession no.
storage temp.
−20°C
Gene Information
cow ... LALBA(281894)
General description
may contain traces of (NH4)2SO4 and sodium phosphateL6010
Application
Biochem/physiol Actions
α-Lactalbumin is the cheif protein in human milk. It consists of a single polypeptide chain with 8 cysteines which form disulfide bridges. α-Lactalbumin binds several metal ions, including calcium, which is thought to play a role in the regeneration of native α-lactalbumin from the reduced, denatured form. α-Lactalbumin also has a distinct zinc binding site that is thought to play a role in the binding of the lactose synthase complex.The mature protein consists of 123 amino acid residues (14 kD), and it has a three-dimensional structure with 1.7 Angstrom resolution, demonstrating four α-helices and a triple stranded antiparallel β-sheet.
Alters the substrate specificity of galactosyltransferase to increase the rate of lactose formation; the complex of galactosyltransferase and α-lactalbumin is called lactose synthase.
Alters the substrate specificity of galactosyltransferase to increase the rate of lactose formation; the complex of galactosyltransferase and α-lactalbumin is called lactose synthase. Site-directed mutagenesis of Asp87 or Asp88 to Ala completely abolishes the strong calcium binding affinity and reduces the stimulation of lactose synthase to <3.5% of the maximal rate.
Analysis Note
May contain traces of (NH4)2SO4 and sodium phosphate.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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