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Merck
CN

L6520

Prolactin from sheep pituitary

20-50 IU/mg

Synonym(s):

LTH, Lactogenic hormone from ovine pituitary glands, Luteotropic Hormone, PRL

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About This Item

CAS Number:
9002-62-4
UNSPSC Code:
51111800
NACRES:
NA.32
MDL number:
MFCD00131553
Form:
powder

Key Documents

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form

powder

specific activity

20-50 IU/mg

solubility

water: 7 mg/mL, clear to slightly hazy, colorless to faintly yellow

UniProt accession no.

P01240

shipped in

ambient

storage temp.

2-8°C

Gene Information

sheep ... PRL(443317)

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Biochem/physiol Actions

Neuroendocrine hormone; belongs to the cytokine hematopoietic receptor family; induces lactation; inhibits secretion of gonadotropins; release is inhibited by dopamine.
Prolactin is a neuroendocrine hormone. The prolactin receptor is a transmembrane glycoprotein that belongs to the cytokine hematopoietic receptor family. A large number of cells and organs express the receptor, including B cells, T cells, macrophages, monocytes and neutrophils. Prolactin signal transduction involves the JAK/STAT families and the src kinase family. Induces lactation; inhibits secretion of gonadotropins; release is inhibited by dopamine.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360

Hazard Classifications

Repr. 1B

Storage Class

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBT9002
SLBT9003
SLBR6354V
SLBR6207V
SLBR3676V

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Sharon R Ladyman et al.
eLife, 10 (2021-09-17)
As part of the maternal adaptations to pregnancy, mice show a rapid, profound reduction in voluntary running wheel activity (RWA) as soon as pregnancy is achieved. Here, we evaluate the hypothesis that prolactin, one of the first hormones to change
Jakub Sumbal et al.
Frontiers in cell and developmental biology, 8, 68-68 (2020-04-09)
Mammary gland development occurs mainly after birth and is composed of three successive stages: puberty, pregnancy and lactation, and involution. These developmental stages are associated with major tissue remodeling, including extensive changes in mammary epithelium, as well as surrounding stroma.
Narattaphol Charoenphandhu et al.
American journal of physiology. Endocrinology and metabolism, 297(3), E609-E619 (2009-07-02)
During pregnancy and lactation, the enhanced intestinal Ca(2+) absorption serves to provide Ca(2+) for fetal development and lactogenesis; however, the responsible hormone and its mechanisms remain elusive. We elucidated herein that prolactin (PRL) markedly stimulated the transcellular and paracellular Ca(2+)
Khalid Bajou et al.
Nature medicine, 20(7), 741-747 (2014-06-16)
The N-terminal fragment of prolactin (16K PRL) inhibits tumor growth by impairing angiogenesis, but the underlying mechanisms are unknown. Here, we found that 16K PRL binds the fibrinolytic inhibitor plasminogen activator inhibitor-1 (PAI-1), which is known to contextually promote tumor
Bibiana Moreno-Carranza et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 305(7), R720-R726 (2013-08-21)
Prolactin (PRL) is a potent liver mitogen and proangiogenic hormone. Here, we used hyperprolactinemic rats and PRL receptor-null mice (PRLR(-/-)) to study the effect of PRL on liver growth and angiogenesis before and after partial hepatectomy (PH). Liver-to-body weight ratio
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