L6914
L-Leucine
Synonym(s):
(S)-2-Amino-4-methylpentanoic acid
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About This Item
Linear Formula:
(CH3)2CHCH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
131.17
UNSPSC Code:
12352209
NACRES:
NA.26
eCl@ss:
32160406
EC Number:
200-522-0
Beilstein/REAXYS Number:
1721722
MDL number:
biological source
non-animal source
assay
≥98.5%
form
crystalline powder
manufacturer/tradename
Ajinomoto
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, heavy metals, residual solvents, tested
solubility
1 M HCl: 50 mg/mL
application(s)
pharmaceutical (small molecule)
foreign activity
cytotoxicity, tested
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General description
To request documentation for this product, please contact Customer Support and select ‘Product Documentation′. Please note that access to the documentation for this product requires a confidentiality disclosure agreement.
Application
L-Leucine is an essential amino acid. It is also considered to be a branched chain amino acid, along with L-Isoleucine and L-Valine. It is used as a cell culture media component in the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies.
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Storage Class
11 - Combustible Solids
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M Sakamoto et al.
The Journal of clinical endocrinology and metabolism, 56(1), 202-204 (1983-01-01)
Recent studies on the nucleotide sequence of cloned DNA complementary to mRNA for preproenkephalin from bovine adrenal medulla and human pheochromocytoma have revealed that this precursor molecule contains four copies of methionine-enkephalin (Met-Enk) and one copy each of leucine-enkephalin (Leu-Enk)
T Yoshimasa et al.
The Journal of clinical investigation, 69(3), 643-650 (1982-03-01)
To elucidate the physiological and pathophysiological significance of methionine- and leucine-enkephalin (Met-and Leu-enkephalin, respectively) in human sympathoadrenal system, the contents of these peptides in normal human sympathetic nervous system, adrenal medulla, and pheochromocytomas were determined by specific radioimmunoassays combined with
Gaetano Santulli et al.
The Journal of clinical investigation, 125(5), 1968-1978 (2015-04-07)
The type 2 ryanodine receptor (RyR2) is a Ca2+ release channel on the endoplasmic reticulum (ER) of several types of cells, including cardiomyocytes and pancreatic β cells. In cardiomyocytes, RyR2-dependent Ca2+ release is critical for excitation-contraction coupling; however, a functional
Marika Leenders et al.
Nutrition reviews, 69(11), 675-689 (2011-10-28)
Amino acids function as precursors for de novo protein synthesis. In addition, however, they play a key role as nutritional signals that regulate multiple cellular processes. There is ample in vitro and in vivo evidence showing that muscle tissue responds
Luc J C van Loon
Current opinion in clinical nutrition and metabolic care, 15(1), 71-77 (2011-11-01)
Amino acids do not merely represent precursors for de-novo protein synthesis, but also function as nutritional signals regulating various metabolic processes. In fact, ample evidence has been generated to show that various tissues respond to changes in amino acid availability
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