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L7527

Sigma-Aldrich

Lipoprotein, very low density from human plasma

≥95% (SDS-PAGE), solution

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Synonym(s):
Pre-β-lipoprotein, VLDL, Very low density lipoprotein
CAS Number:
308068-14-6
MDL number:
MFCD00164409
NACRES:
NA.25

biological source

human plasma

Quality Level

200

Assay

≥95% (SDS-PAGE)

form

solution

UniProt accession no.

P02649
P02655
P04114

functional group

ester
phospholipid

shipped in

wet ice

storage temp.

2-8°C

Gene Information

human ... APOB(338) , APOC2(344) , APOE(348)

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Biochem/physiol Actions

VLDL (Very low density lipoprotein) may be used to study the mechanisms and effects of very low density receptors (VLDLR). VLDL is used as a potential source of fatty acids that support cardiac energy metabolism. VLDL is often studied to differentiate its effects from those of chylomicrons.
Inhibits DNA synthesis in lymphocytes activated by the nonspecific mitogen concanavalin A (Con A).

Physical form

Solution in 150 mM NaCl and 0.01% EDTA, pH 7.4

Other Notes

View more information on lipoprotein function and lipid transport at www.sigma-aldrich.com/enzymeexplorer

Regulatory Information

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Akifumi Kushiyama et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(8), 1986-1993 (2013-05-25)
Resistin-like molecule (RELM) β is a secretory protein homologous to resistin and reportedly contributes to local immune response regulation in gut and bronchial epithelial cells. However, we found that activated macrophages also express RELMβ and thus investigated the role of
M C Sampedro et al.
Biochemical and biophysical research communications, 285(2), 393-399 (2001-07-11)
Human very-low-density lipoprotein (VLDL) inhibits DNA synthesis in lymphocytes activated by the nonspecific mitogen concanavalin A (Con A). We studied the effects of VLDL on lymphocyte activation (IL-2 receptor expression), cell cycle progression, and production of IL-2 and of IL-4
Matthew R Sobansky et al.
Analytical and bioanalytical chemistry, 406(25), 6203-6211 (2014-08-12)
High-performance affinity chromatography (HPAC) was utilized to examine the binding of very low density lipoprotein (VLDL) with drugs, using R/S-propranolol as a model. These studies indicated that two mechanisms existed for the binding of R- and S-propranolol with VLDL. The
You-Guo Niu et al.
Journal of lipids, 2011, 189876-189876 (2011-07-21)
The heart is a major consumer of energy and is able to utilise a wide range of substrates including lipids. Nonesterified fatty acids (NEFA) were thought to be a favoured carbon source, but their quantitative contribution is limited because of
Katsuyuki Nakajima et al.
Clinica chimica acta; international journal of clinical chemistry, 412(15-16), 1306-1318 (2011-05-03)
Since Zilversmit first proposed postprandial lipemia as the most common risk of cardiovascular disease, chylomicrons (CM) and CM remnants have been thought to be the major lipoproteins which are increased in the postprandial hyperlipidemia. However, it has been shown over
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