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L8275

Lectin from Galanthus nivalis (snowdrop)

lyophilized powder

Synonym(s):

Galanthus nivalis lectin, GNL

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.32
MDL number:
MFCD00163718
Form:
lyophilized powder
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form

lyophilized powder

Quality Segment

potency

<20 μg per mL agglutination activity

composition

Protein, ≥90% Lowry

impurities

salt, essentially free

storage temp.

2-8°C

General description

Lectin from Galanthus nivalis (snowdrop) is a tetrameric, 12 kDa mannose binding lectin. It belongs to the family, Amaryllidacea. It is specific to α-1,3- or 1,6- linked D-mannose of carbohydrates. Snowdrop lectins are toxic to insects.

Application

Lectin from Galanthus nivalis (snowdrop) has been used:
  • to coat ELISA plates
  • as reverse transcriptase inhibitor
  • in ELISA for detection of envelope glycoproteins of the human and simian immunodeficiency viruses

Biochem/physiol Actions

Lectin from Galanthus nivalis (snowdrop) provide resistance against pests and are used in transgenic plants. Snowdrop lectin functions as a carrier to transport fused proteins to the hemolymph as it crosses gut epithelium of target species to exhibit insecticidal effects.
GNL agglutinates rabbit erythrocytes; human erythrocytes are not agglutinated. GNL sugar specificity is directed to the nonreducing end of the terminal α-D-mannosyl residue of glycoconjugates.

Preparation Note

Purified by affinity chromatography according to Kaku.

Analysis Note

Agglutination activity is expressed in μg/ml and is determined from serial dilution in phosphate buffered saline, pH 7.2 of a 1 mg per mL solution. This activity is the lowest concentration to agglutinate a 2% suspension of rabbit erythrocytes after 1 hr incubation at 25 °C.

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Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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