L8397
ʟ-Leucinethiol
leucine aminopeptidase inhibitor, solid
Synonym(s):
Dithiobis(2-amino-4-methylpentane)
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About This Item
Empirical Formula (Hill Notation):
C12H28N2S2 · 2HCl
CAS Number:
Molecular Weight:
337.42
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Product Name
L-Leucinethiol, oxidized dihydrochloride, leucine aminopeptidase inhibitor
Quality Level
form
solid
storage temp.
−20°C
SMILES string
CC(C)C[C@H](N)CS
InChI
1S/C6H15NS/c1-5(2)3-6(7)4-8/h5-6,8H,3-4,7H2,1-2H3/t6-/m0/s1
InChI key
GXEDNWSUKCJLLB-LURJTMIESA-N
Application
Upon reduction in vivo to L-leucinethiol, compound is a potent inhibitor of leucine aminopeptidase.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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T D Ocain et al.
Biochemical and biophysical research communications, 145(3), 1038-1042 (1987-06-30)
L-Lysinethiol was found to be an extremely potent inhibitor of aminopeptidase B (AP-B) with a Ki = 9.1 X 10(-10) M. L-leucinethiol was also a potent inhibitor of AP-B (kj = 1.3 X 10(-7) M), while the D-isomer was much
W W Chan
Biochemical and biophysical research communications, 116(1), 297-302 (1983-10-14)
L-leucinthiol (2-amino-4-methyl-1-pentanethiol) was designed as an inhibitor of leucine aminopeptidase by analogy with sulfhydryl inhibitors of other zinc-containing peptidases. It was synthesized from L-leucinol and shown to be a potent competitive inhibitor of the microsomal aminopeptidase from porcine kidney (Ki
D S Pickering et al.
Archives of biochemistry and biophysics, 239(2), 368-374 (1985-06-01)
L-Leucinthiol, a synthetic derivative of mercaptoethylamine with a hydrophobic side chain, was recently reported to be a potent inhibitor of microsomal aminopeptidase. The structural features necessary for interaction of mercaptoamines with this enzyme have now been explored more systematically. Optimal
Global Trade Item Number
| SKU | GTIN |
|---|---|
| L8397-5MG | 04061833272596 |
| L8397-1MG | 04061826683699 |