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L9151

Lys-Lys-Lys-Lys-Lys

Name: Lys-Lys-Lys-Lys-Lys
Brand: SIGMA

≥55% peptide basis, Bioreagent

Synonym(s):

Lys5, Pentalysine

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About This Item

Empirical Formula (Hill Notation):

C₃₀H₆₂N₁₀O₆

CAS Number:

19431-21-1

Molecular Weight:

658.88

UNSPSC Code:

12352209

PubChem Substance ID:

24896518

NACRES:

NA.26

MDL number:

MFCD00083765

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Properties

Product Name

Lys-Lys-Lys-Lys-Lys, ≥55% peptide basis

form

powder

composition

Peptide content, ~60%

concentration

≥55% (peptide)

color

white

storage temp.

−20°C

SMILES string

NCCCCC(N)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(O)=O

InChI

1S/C30H62N10O6/c31-16-6-1-11-21(36)26(41)37-22(12-2-7-17-32)27(42)38-23(13-3-8-18-33)28(43)39-24(14-4-9-19-34)29(44)40-25(30(45)46)15-5-10-20-35/h21-25H,1-20,31-36H2,(H,37,41)(H,38,42)(H,39,43)(H,40,44)(H,45,46)

InChI key

IXPHOHNWDLRFJH-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Short poly-L-lysines polypeptides such as trilysine (lys3), tetralysine (tetra-L-lysine, lys4) and pentalysine (penta-L-lysine, lys5) are cationic moieties that may be used in the construction of gene delivery vectors and DNA nanoparticles.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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2H and 31P NMR study of pentalysine interaction with headgroup deuterated phosphatidylcholine and phosphatidylserine.

M Roux et al.

European biophysics journal : EBJ, 16(5), 267-273 (1988-01-01)

The interaction of cationic pentalysine with phospholipid membranes was studied by using phosphorus and deuterium Nuclear Magnetic Resonance (NMR) of headgroup deuterated dimyristoyl phosphatidylcholine (DMPC) and dimyristoyl phosphatidylserine (DMPS). In the absence of pentalysine, some of the deuterium and phosphorus

Pharmacologic activation of cholinergic alpha7 nicotinic receptors mitigates depressive-like behavior in a mouse model of chronic stress.

Dan Zhao et al.

Journal of neuroinflammation, 14(1), 234-234 (2017-12-05)

It has been shown that chronic stress-induced depression is associated with exaggerated inflammatory response in the brain. Alpha7 nicotinic acetylcholine receptors (α7nAChRs) regulate the cholinergic anti-inflammatory pathway, but the role of cholinergic signaling and α7nAChR in chronic stress has not

Pentalysine-deoxyribonucleic acid interactions: a model for the general effects of ion concentrations on the interactions of proteins with nucleic acids.

T M Lohman et al.

Biochemistry, 19(15), 3522-3530 (1980-07-22)

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Global Trade Item Number

SKU	GTIN
L9151-50MG	04061832821733
L9151-10MG	04061832821726