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L9167

LWH-63 hydrochloride

Name: LWH-63 hydrochloride
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

4-(N-Ethyl-n-4-hydroxybutyl)amino-2,5,6-trimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidine hydrochloride, NIH-3

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About This Item

Empirical Formula (Hill Notation):

C₂₄H₃₅ClN₄O

CAS Number:

276890-57-4

Molecular Weight:

431.01

NACRES:

NA.77

PubChem Substance ID:

24724529

UNSPSC Code:

12352200

MDL number:

MFCD07784506

Assay:

≥98% (HPLC)

Form:

solid

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Properties

assay

≥98% (HPLC)

form

solid

color

light brown

solubility

DMSO: ~10 mg/mL, H₂O: insoluble

storage temp.

2-8°C

SMILES string

Cl[H].CCN(CCCCO)c1nc(C)nc2n(c(C)c(C)c12)-c3c(C)cc(C)cc3C

InChI

1S/C24H34N4O.ClH/c1-8-27(11-9-10-12-29)23-21-18(5)19(6)28(24(21)26-20(7)25-23)22-16(3)13-15(2)14-17(22)4;/h13-14,29H,8-12H2,1-7H3;1H

InChI key

DKVWSJKPRJIFPC-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Non-peptide CRF₁ corticotrophin-releasing factor antagonist.

Non-peptide CRF₁ corticotrophin-releasing factor antagonist. K_i = 0.68 nM; blocks ethanol-induced effects as well as CRF effects in mice, suggesting a possible therapeutic target for the treatment of stress-induced alcohol drinking.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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