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L9277

Anti-Leukemia Inhibitory Factor antibody produced in goat

Name: Anti-Leukemia Inhibitory Factor antibody produced in goat
Brand: SIGMA

IgG fraction of antiserum, lyophilized powder

Synonym(s):

Anti-LIF

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About This Item

UNSPSC Code:

51111800

NACRES:

NA.41

MDL number:

MFCD00212999

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Neutral

Citations:

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Properties

biological source

goat

Quality Level

100

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

human

technique(s)

neutralization: suitable

UniProt accession no.

P15018

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... LIF(3976)

Description

General description

Leukemia inhibitory factor (LIF) is a pleotrophic glycoprotein that belongs to the IL6 family of cytokines. It is secreted by many cell types such as, fibroblasts, macrophages, T cells, monocytes, liver cells, osteoblasts and cells of endometrium. LIF interacts with a heterodimeric receptor composed of two subunits, gp130 and gp190. A variety of signal transduction pathways are triggered in response to LIF including ERK/MAPK, JAK1, PI3K, STAT3, Jun-cFos and NF-κB. The various functions of LIF include proliferation of adult human T cells, maintenance of pluripotency of embryonic stem cells and inhibition of leukemic ell differentiation. Reports also indicate the important role of LIF in lactation, tissue regeneration after brain and spinal cord injury, muscle regeneration and motor neuron functions.
Anti-Leukemia Inhibitory Factor recognizes human leukemia inhibitory factor. It shows no cross-reactivity with recombinant mouse LIF.

Immunogen

recombinant human LIF expressed in E. coli

Application

Anti-Leukemia Inhibitory Factor antibody may be for immunoblotting a concentration of 1 μg/ml For ELISA a working concentration of 1 μg/ml is recommended. The antibody is suitable for neutralization reactions. For neutralization of LIF in SEK1, melanoma cell line, a concentration of 100 μg/ml was used.

Biochem/physiol Actions

The antibody neutralizes the biological activity of recombinant human LIF.

Physical form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline

Preparation Note

Purified using protein G

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Global Trade Item Number

SKU	GTIN
L9277-1MG	04061823124829