L9776
Leucine Aminopeptidase, microsomal from porcine kidney
suitable for protein sequencing, BioReagent, lyophilized powder
Synonym(s):
Aminopeptidase M, Aminopeptidase N, Cathepsin III, LAP, Leucinamide aminopeptidase, Leucinaminopeptidase
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About This Item
CAS Number:
UNSPSC Code:
12352200
NACRES:
NA.26
EC Number:
232-942-5
MDL number:
product line
BioReagent
form
lyophilized powder
packaging
vial of 50 μg
suitability
suitable for protein sequencing
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
−20°C
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General description
Leucine Aminopeptidase (LAP) is a proteolytic enzyme. It is an amino acid hydrolase that catalyzes the hydrolysis of leucine residues from the amino-terminal of proteins or peptides. LAP is naturally present in the liver, kidney, lung, and serum.
Application
Leucine Aminopeptidase has been used:
- in proteomics analysis
- as a treatment for protein depolymerization reaction
- to test its effect on the degradation of human recombinant IL-8
Biochem/physiol Actions
Leucine Aminopeptidase serves as a biomarker for drug-induced liver injury because in case of liver injury, cirrhosis, hepatitis, and other disorders serum LAP activity increases. Abnormal expression of LAP results in tumor cell proliferation, angiogenesis, and invasion, so it can also serve as a cancer-related biomarker.
Other Notes
One unit will hydrolyze 1.0 μmole of L-leucine-p-nitroanilide to L-leucine and p-nitroaniline per min at pH 7.2 at 37 °C. (At 25 °C, approx. 40% of the activity at 37 °C is obtained.) The activity obtained using L-leucine p-nitroanilide as substrate is 2-5 times that obtained with L-leucinamide as substrate.
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
低风险生物材料
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Materials today chemistry, 15, 100216-100216 (2020)
Yong Huang et al.
Analytical chemistry, 91(13), 8085-8092 (2019-05-31)
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