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M003

R-(−)-Deprenyl hydrochloride

Name: <I>R</I>-(&#8722;)-Deprenyl hydrochloride
Brand: SIGMA

≥98% (HPLC), MAO-B inhibitor, powder

Synonym(s):

(R)-(−)-N,α-Dimethyl-N-(2-propynyl)phenethylamine hydrochloride, R(−)-N-α-Dimethyl-N-2-propynyl-benzeneethanamine hydrochloride, Selegiline hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₃H₁₇N · HCl

CAS Number:

14611-52-0

Molecular Weight:

223.74

UNSPSC Code:

12352200

PubChem Substance ID:

24278577

NACRES:

NA.77

MDL number:

MFCD00069299

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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Product Name

R-(−)-Deprenyl hydrochloride, powder, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]25/D −10.8°, c = 6.48 in H₂O(lit.)

color

white

mp

141-142 °C

solubility

H₂O: >10 mg/mL

originator

Sanofi Aventis

SMILES string

Cl[H].C[C@H](Cc1ccccc1)N(C)CC#C

InChI

1S/C13H17N.ClH/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13;/h1,5-9,12H,10-11H2,2-3H3;1H/t12-;/m1./s1

InChI key

IYETZZCWLLUHIJ-UTONKHPSSA-N

Gene Information

human ... MAOB(4129)

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Biochem/physiol Actions

Selective MAO-B inhibitor; anti-Parkinsonian agent.

Features and Benefits

This compound is featured on the Dopamine and Norepinephrine Metabolism and Histamine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS07

signalword

Warning

hcodes

H302,H336

pcodes

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral - STOT SE 3

target_organs

Central nervous system

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

0000529503

0000477504

0000340007

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Social odor recognition: a novel behavioral model for cognitive dysfunction in Parkinson's disease.

Michael M Monaghan et al.

Neuro-degenerative diseases, 7(1-3), 153-159 (2010-03-04)

Parkinson's disease (PD) is a progressive neurodegenerative condition characterized by an increasing loss of dopaminergic neurons resulting in motor dysfunction. However, cognitive impairments in PD patients are a common clinical feature that has gained increased attention. The purpose of the

Identification of Sarmentosin as a Key Bioactive from Blackcurrants (Ribes nigrum) for Inhibiting Platelet Monoamine Oxidase in Humans.

Dominic Lomiwes et al.

Journal of agricultural and food chemistry, 72(30), 16777-16789 (2024-07-19)

Previous clinical studies indicate that monoamine oxidase-B (MAO-B) inhibition by blackcurrants must be predominantly attributed to bioactives other than anthocyanins. In this natural products discovery study, MAO-A/B inhibitory phytochemicals were isolated from blackcurrants, and a double-blind crossover study investigated the

Inhibition of monoamine oxidase-a increases respiration in isolated mouse cortical mitochondria.

Olivia J Kalimon et al.

Experimental neurology, 363, 114356-114356 (2023-02-26)

Monoamine oxidase (MAO) is an enzyme located on the outer mitochondrial membrane that metabolizes amine substrates like serotonin, norepinephrine and dopamine. MAO inhibitors (MAOIs) are frequently utilized to treat disorders such as major depression or Parkinson's disease (PD), though their

Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS.

Hojae Lee et al.

Nature neuroscience, 24(12), 1673-1685 (2021-11-17)

Amyotrophic lateral sclerosis (ALS) is a devastating disorder in which motor neurons degenerate, the causes of which remain unclear. In particular, the basis for selective vulnerability of spinal motor neurons (sMNs) and resistance of ocular motor neurons to degeneration in

The effect of deprenyl (selegiline) on the natural history of Parkinson's disease.

J W Tetrud et al.

Science (New York, N.Y.), 245(4917), 519-522 (1989-08-04)

The effects of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), a neurotoxin that produces the symptoms of Parkinson's disease, can be fully prevented in experimental animals by inhibiting monoamine oxidase B. On the basis of this observation, a double-blind, placebo-controlled study in patients with early

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Global Trade Item Number

SKU	GTIN
M003-1G	04061835512720
M003-250MG	04061835557653

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