M0689
Myelin Basic Protein Antigen from human brain
≥95% (SDS-PAGE)
Synonym(s):
Myelin Antigen, Myelin Basic Protein
Application
Myelin basic protein antigen from human brain has been used in enzyme-linked immunosorbent spot assays.
Biochem/physiol Actions
Determined using polyclonal and monoclonal antibodies against MBP.
Myelin basic protein (MBP) plays a vital role in formation of myelin sheath and is associated with the various neurological disorders. MBP function as an antigenic target in autoimmune disease experimental allergic encephalomyelitis (EAE). It also has a crucial role to play in human demyelinating diseases including multiple sclerosis (MS). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositides and regulation of calcium homoeostasis.
General description
Myelin basic protein (MBP) is an 18.5kDa protein encoded by the gene mapped to human chromosome 18q22qter. MBP is a major component of myelin sheath and is highly expressed in central nervous system (CNS).
Other Notes
Blood samples from donors were tested and found to be negative for HBsAg, HIV-1 and HIV-2 antibodies, HCV.
Physical form
Lyophilized from 10mM HCl.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Distinct T cell signatures define subsets of patients with multiple sclerosis.
Johnson MC
Neurology? neuroimmunology & neuroinflammation, 3(5), e278-e278 (2016)
Localization of the human myelin basic protein gene (MBP) to region 18q22----qter by in situ hybridization.
Saxe DF
Cytogenetics and Cell Genetics, 39(4), 246-249 (1985)
MyelStones: the executive roles of myelin basic protein in myelin assembly and destabilization in multiple sclerosis.
Vassall KA
The Biochemical Journal, 472(1), 17-32 (2015)
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