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M0880

Sigma-Aldrich

Ethyl methanesulfonate

liquid

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Synonym(s):
Ethyl mesylate, Methanesulfonic acid ethyl ester
Linear Formula:
CH3SO3CH2CH3
CAS Number:
62-50-0
Molecular Weight:
124.16
Beilstein:
773969
EC Number:
200-536-7
MDL number:
MFCD00007559
PubChem Substance ID:
24896575
NACRES:
NA.25

form

liquid

refractive index

n20/D 1.418 (lit.)

bp

85-86 °C/10 mmHg (lit.)

density

1.206 g/mL at 20 °C

SMILES string

CCOS(C)(=O)=O

InChI

1S/C3H8O3S/c1-3-6-7(2,4)5/h3H2,1-2H3

InChI key

PLUBXMRUUVWRLT-UHFFFAOYSA-N

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Application

Ethyl methanesulfonate had been used for inducing mutation in mouse embryonic fibroblasts, yeast human embryonic kidney cell lines and human lymphocytes.

Biochem/physiol Actions

Ethyl methanesulfonate is a DNA ethylating agent, mutagenic to plants and animals and carcinogenic in mammals. It has been used as a model alkylating agent in studies of DNA repair processes. EMS induces base substitutions of guanine-cytosine (G/C) to adenine-thymine (A/T). EMS also generates point mutations and single nucleotide polymorphisms in genomes. EMS is potential chemical mutagen used for inducing mutation in rice, wheat and Arabidopsis thaliana.

Pictograms

Exclamation markHealth hazard
GHS07,GHS08

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 2 - Skin Irrit. 2 - Skin Sens. 1

Storage Class Code

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

212.0 °F

Flash Point(C)

100 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. I have heard that I need to use sodium thiosulfate with Product M0880, Ethyl methanesulfonate (EMS), but I’m not sure how. Can you tell me?

    EMS is a mutagen. After treating cells with EMS, the mutagenesis reaction may be stopped by adding the appropriate volume of a 5% sodium thiosulfate solution.The use of a 10% sodium thiosulfate solution with 1% TWEEN 20 has been used to clean surfaces and items such as pipettes that have been contaminated with EMS in mineral oil.

  4. Is Product M0880, Ethyl methanesulfonate (EMS), sterile?

    It is not necessarily sterile. For those applications that require a sterile EMS solution, the EMS should be added to the appropriate buffer or medium. The buffer or medium should then be sterile-filtered.

  5. I received a liquid. What is Product M0880, Ethyl methanesulfonate (EMS), dissolved in?

    It’s actually not dissolved in anything. Pure EMS is itself a liquid at room temperature; that is, the melting point is below room temperature.

  6. How does Product M0880, Ethyl methanesulfonate (EMS), compare to Product 64292, which is the same chemical?

    Product No. 64292 is tested for purity by a titration assay. Although M0880 is likely to be of similar quality, there is no purity assay performed on it.

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  8. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  9. My question is not addressed here, how can I contact Technical Service for assistance?

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In vitro mutation induction of Saintpaulia using ethyl methanesulfonate
Fang JY and Traore S
Hortscience: a Publication of the American Society For Horticultural Science Hortscience, 46(7), 981-984 (2011)
The effects of thymol on sister chromatid exchange, chromosome aberration and micronucleus in human lymphocytes
Buyukleyla M and Rencuzogullari E
Ecotoxicology and Environmental Safety, 72(3), 943-947 (2009)
Kamel El Omari et al.
Nature communications, 10(1), 846-846 (2019-02-21)
Lipid membrane fusion is an essential function in many biological processes. Detailed mechanisms of membrane fusion and the protein structures involved have been mainly studied in eukaryotic systems, whereas very little is known about membrane fusion in prokaryotes. Haloarchaeal pleomorphic
A Rapid and Precise Mutation-Activated Fluorescence Reporter for Analyzing Acute Mutagenesis Frequency
Birnbaum MD, et al.
Cell Chemical Biology (2018)
Yu-Long Gao et al.
Journal of integrative plant biology, 62(2), 165-180 (2019-01-31)
Targeting-induced local lesions in genomes (TILLING) is a powerful reverse-genetics tool that enables high-throughput screening of genomic variations in plants. Although TILLING has been developed for many diploid plants, the technology has been used in very few polyploid species due
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