M0939
Anti-α-MSH antibody produced in rabbit
IgG fraction of antiserum, buffered aqueous solution
Synonym(s):
Anti-α-Melanocyte Stimulating Hormone
Product Name
Anti-α-MSH antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 1664.9 kDa
species reactivity
human
technique(s)
ELISA: 1:4,000
microarray: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... POMC(5443)
Application
Anti-α-MSH antibody produced in rabbit has been used in:
- immunohistochemistry
- radioimmunoassay/α-MSH immunoassay
- enzyme linked immunosorbent assay (ELISA)
Biochem/physiol Actions
α-MSH (melanocyte stimulating hormone) and melanocortin-4-receptor (MC4R) are key signaling components in the control of energy homeostasis and of the hypothalamic response to obesity. Mutations that reduce the functional activity of -MSH lead to obesity in mammals and mice lacking the MC4 receptor (MC4R-/-) are hyperphagic and very obese, indicating that -MSH signaling transduced by MC4-R limits food intake and body fat mass.
α-Melanocyte Stimulating Hormone (α-MSH) stimulates the production of melanin in melanocytes and induced pigmentation and skin darkening. It increases the activity of tyrosinase that induces melanogenesis. α-MSH has potent anti-inflammatory effects and is also a neuromodulator. Analogs of α-MSH may be used to study melanogenesis and neuromodulation.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Pro-opiomelanocortin (POMC), a complex pro-peptide is expressed in hypothalamus, pituitary gland, skin and the immune system. This gene is located on human chromosome 2p23.3.
Immunogen
synthetic α-MSH peptide conjugated to bovine serum albumin.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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V U Emelianov et al.
The British journal of dermatology, 166(5), 1023-1034 (2011-12-06)
The cause of follicular occlusion, a key early event in the pathogenesis of hidradenitis suppurativa (HS), also known as acne inversa, remains unknown. To identify changes, if any, in the antimicrobial peptide (AMP) and cytokine expression profile of HS affected
N Rajora et al.
Journal of leukocyte biology, 59(2), 248-253 (1996-02-01)
alpha-Melanocyte-stimulating hormone (alpha-MSH), a tridecapeptide derived from pro-opiomelanocortin, has potent antiinflammatory activity in laboratory animals. alpha-MSH inhibits nitric oxide production by murine macrophages, an influence believed to reflect activation of an autocrine circuit in these cells, one that is based
Genetic dissection of the mechanisms underlying telomere-associated diseases: impact of the TRF2 telomeric protein on mouse epidermal stem cells
Stout GJ and Blasco MA
Disease models & mechanisms, 2(3-4), 139-156 (2009)
alpha-Melanocyte stimulating hormone promotes muscle glucose uptake via melanocortin 5 receptors
Enriori PJ, et al.
Molecular Metabolism, 5(10), 807-822 (2016)
Molecular Therapy of Melanocortin-4-Receptor Obesity by an Autoregulatory BDNF Vector
Siu JJ, et al.
Molecular therapy. Methods & clinical development, 7, 83-95 (2017)
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