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M1028

Magnesium chloride solution

Name: Magnesium chloride solution
Brand: SIGMA

Molecular Biology, 1.00 M±0.01 M

Synonym(s):

MgCl₂, dichloromagnesium, magnesium chloride

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About This Item

Linear Formula:

MgCl₂

CAS Number:

7786-30-3

Molecular Weight:

95.21

NACRES:

NA.52

PubChem Substance ID:

24896582

UNSPSC Code:

12352302

MDL number:

MFCD00011106

Grade:

Molecular Biology

Form:

liquid

Solubility:

water: soluble

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grade

Molecular Biology

Quality Level

300

sterility

non-sterile; 0.2 μm filtered

form

liquid

concentration

1.00 M±0.01 M

technique(s)

DNA sequencing: suitable

impurities

DNAse, none detected, NICKase, none detected, Protease, none detected, RNAse, none detected

solubility

water: soluble

density

1.080 g/cm³

cation traces

heavy metals (as Pb): ≤5 ppm

suitability

suitable for electrophoresis, suitable for molecular biology

application(s)

cell analysis

foreign activity

DNase, RNase, NICKase and protease, none detected

SMILES string

Cl[Mg]Cl

InChI

1S/2ClH.Mg/h2*1H;/q;;+2/p-2

InChI key

TWRXJAOTZQYOKJ-UHFFFAOYSA-L

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Lab Chemicals

Salts

General description

Magnesium chloride is a common ionic halide that readily dissolves in water. It plays various crucial biological roles in enzymology, cell membrane/wall structure, muscle cell physiology, and nucleic acid composition. Additionally, magnesium chloride serves as an essential co-factor in numerous enzymes, including DNAse, specific restriction enzymes, and Ribonuclease H. It is widely utilized to provide magnesium ions in diverse molecular biology applications, including PCR reactions.

Application

Magnesium chloride is widely used to supply the magnesium ion in various molecular biology applications, including PCR reactions and buffers. It has been used -

to prepare buffer to lyse cells for immunoprecipitation
as a supplement in Krebs-Henseleit buffer in chronic high-fat diet studies of aged mice.
in embedding 3-dimensional mtgase hydrogels in invitro studies of osteocyte differentitaion and interconnected cellular networks.
It has been used to protect the liver from oxidative damage.
to prepare serum-free medium for electrophysiological studies of rat brain slice cultures.

Features and Benefits

Available as a Ready-to-use solution which reduces the need for preparation time.
Heavy metals (as Pb): ≤5 ppm
Free from DNase, RNase, NICKase and protease

Other Notes

For additional information on our range of Biochemicals, please complete this form.

Magnesium chloride solution contains 1M magnesium chloride in 18 megaohm water.

Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

ppe

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Protective Effects of Magnesium Chloride on Liver Enzymes and Biomarkers of Oxidative Stress in high fat diet fed Rats

Mohammed et, al

Nigerian Journal of Physiological Sciences : Official Publication of the Physiological Society of Nigeria, 34(2), 149-157 (2019)

Osteocyte differentiation and the formation of an interconnected cellular network in vitro.

M J Mc Garrigle et al.

European cells & materials, 31, 323-340 (2016-05-25)

Extracellular matrix (ECM) stiffness and cell density can regulate osteoblast differentiation in two dimensional environments. However, it is not yet known how osteoblast-osteocyte differentiation is regulated within a 3D ECM environment, akin to that existing in vivo. In this study

Insulin-like growth factor-1 lowers spreading depression susceptibility and reduces oxidative stress.

Yelena Y Grinberg et al.

Journal of neurochemistry, 122(1), 221-229 (2012-04-25)

Spreading depression (SD), the likely cause of migraine aura and perhaps migraine, is triggered by widespread and unfettered neuronal hyperexcitability. Migraine and the initiating hyperexcitability of seizure, which involve oxidative stress (OS), are likely interrelated. Environmental enrichment (EE) decreases seizure

Analysis of androgen receptor rapid actions in cellular signaling pathways: receptor/Src association.

Antimo Migliaccio et al.

Methods in molecular biology (Clifton, N.J.), 776, 361-370 (2011-07-29)

Much evidence indicates that, with few exceptions, non-genomic actions of steroids are mediated by receptors universally known as nuclear receptors. Steroid receptors do not exhibit intrinsic tyrosine kinase activity. Nevertheless, they stimulate different signaling pathways in cytoplasm of target cells

A chronic high-fat diet exacerbates contractile dysfunction with impaired intracellular Ca2+ release capacity in the skeletal muscle of aged mice.

Hiroaki Eshima et al.

Journal of applied physiology (Bethesda, Md. : 1985), 128(5), 1153-1162 (2020-03-28)

Obesity and aging reduce skeletal muscle contractile function. However, it remains unclear whether obesity additively promotes muscle contractile dysfunction in the setting of aging. In this study, we investigated skeletal muscle contractile function ex vivo and intracellular Ca2+ release in

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Diethanolamine Assay for the Enzymatic Assay of Alkaline Phosphatase (EC 3.1.3.1)

Enzymatic Assay of Alkaline Phosphatase, Diethanolamine Assay (EC 3. 1. 3. 1)

Enzymatic Assay of Glucose-6-Phosphate Dehydrogenase (EC 1.1.1.49)

To measure glucose-6-phosphate dehydrogenase activity, beta-nicotinamide adenine dinucleotide phosphate is used in a spectrophotometric rate determination assay at 340 nm.

Enzymatic Assay of Hexokinase

Measure hexokinase activity using a continuous spectrophotometric rate-determination assay at 340 nm, catalyzing D-hexose sugar phosphorylation using ATP.

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Global Trade Item Number

SKU	GTIN
M1028-10X1ML	04061834037774
M1028-100ML	04061838258427

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