Anti-Mucolipin-3 (C-terminal) antibody produced in rabbit

Mucolipin-3 (MLN3) belongs to mucolipin subfamily. It consists of six transmembrane domain (TMD), with a putative pore region between TMD5 and TMD6 and cytosolic N- and C-termini. MLN3 is a Ca²⁺ permeable cation channel, which is expressed in the plasma membrane, endosomes, lysosomes and autophagosomes.

synthetic peptide corresponding to amino acids 529-542 of human mucolipin-3. This sequence is identical in mouse and rat mucoplipin-3.

Anti-Mucolipin-3 (C-terminal) antibody produced in rabbit has been used in immunoblotting.

Additional bands may be observed at ~150 kDa and ~50 kDa due to aggregation and degradation, respectively.

Mucolipin-3 (MLN3) regulates endocytic pathway and lysosomal integrity. It modulates membrane trafficking and autophagy. Abnormalities of transient receptor potential cation channel, mucolipin subfamily, member 3 (TRPML3) are linked to early deafness, pigmentation abnormalities, and perinatal lethality in mice. Mutations in mouse mucolipin-3 encoded by the MCOLN3 gene, are associated with deafness and pigmentation defects in varitint-waddler mice.

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

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