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M108

(−)-MK-801 hydrogen maleate

≥98% (HPLC)

Synonym(s):

(5R,10S)-(–)-5-Methyl-10,11-dihydro-5H-dibenzo­[a,d]­cyclo­hepten-5,10-imine hydrogen maleate

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About This Item

Empirical Formula (Hill Notation):
C16H15N · C4H4O4
CAS Number:
77086-19-2
Molecular Weight:
337.37
UNSPSC Code:
12352200
PubChem Substance ID:
24277961
MDL number:
MFCD00082466
Assay:
≥98% (HPLC)
Form:
solid
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Quality Segment

100

assay

≥98% (HPLC)

form

solid

optical activity

[α]25/D −117.7°, c = 1 in methanol(lit.)

color

white

solubility

DMSO: >20 mg/mL

storage temp.

room temp

SMILES string

[H]\C(=C(/[H])C(O)=O)C(O)=O.[H][C@@]12Cc3ccccc3[C@@](C)(N1)c4ccccc24

InChI

1S/C16H15N.C4H4O4/c1-16-13-8-4-2-6-11(13)10-15(17-16)12-7-3-5-9-14(12)16;5-3(6)1-2-4(7)8/h2-9,15,17H,10H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t15-,16+;/m0./s1

InChI key

QLTXKCWMEZIHBJ-FWHYOZOBSA-N

Gene Information

human ... GRIN1(2902), GRIN2C(2905), GRIN2D(2906), GRIN3A(116443), GRIN3B(116444), GRINA(2907)
mouse ... GRIN1(14810), GRIN2C(14813), GRIN2D(14814), GRIN3A(242443), GRIN3B(170483), GRINA(66168)
rat ... GRIN1(24408), GRIN2C(24411), GRIN2D(24412), GRIN3A(191573), GRIN3B(170796), GRINA(266668)

General description

(-)-MK-801 hydrogen maleate is a less potent stereoisomer of (+)-MK-801.

Biochem/physiol Actions

MK-801 functions as a selective non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist.
Less active enantiomer of (+)-MK-801 hydrogen maleate

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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