M109
2-Methylserotonin maleate salt
≥98% (HPLC)
Synonym(s):
2-Methyl-5-hydroxytryptamine maleate salt, 3-(2-Aminoethyl)-2-methyl-1H-indol-5-ol maleate salt
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About This Item
Empirical Formula (Hill Notation):
C11H14N2O · C4H4O4
CAS Number:
Molecular Weight:
306.31
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
SMILES string
OC(=O)\C=C/C(O)=O.Cc1[nH]c2ccc(O)cc2c1CCN
assay
≥98% (HPLC)
form
solid
color
tan
solubility
H2O: 4.5 mg/mL
storage temp.
−20°C
Gene Information
human ... HTR3A(3359), HTR3B(9177)
Biochem/physiol Actions
5-HT3 serotonin receptor agonist.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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D M Gillies et al.
European journal of pharmacology, 303(1-2), 1-12 (1996-05-06)
5-Hydroxytryptamine (5-HT) is involved in the modulation of dopaminergic activity in the mesolimbic system, but its sites of action and the receptors involved are not well understood. Locomotor activity responses in rats were monitored in Animex automated activity boxes following
T Endo et al.
Research communications in molecular pathology and pharmacology, 104(2), 145-155 (2000-01-14)
The object of this study was to evaluate the involvement of 5-HT3 receptors in the regulation of 5-HT release from the small intestine using ferrets, an animal model of emesis. 2-Methyl-5-HT, a 5-HT3 receptor agonist, produced a concentration-dependent increase of
A M Ismaiel et al.
Journal of medicinal chemistry, 33(2), 755-758 (1990-02-01)
alpha-Methyl-5-hydroxytryptamine (alpha-Me-5-HT; 2) and 2-methyl-5-hydroxytryptamine (2-Me-5-HT; 3) are considered to be 5-HT2-selective and 5-HT3-selective agents, respectively. These agents were synthesized and examined at serotonin (5-HT) binding sites because there is relatively little documentation as to their selectivity and because they
Weixia Zhong et al.
PloS one, 9(8), e104718-e104718 (2014-08-15)
Stimulation of 5-HT3 receptors (5-HT3Rs) by 2-methylserotonin (2-Me-5-HT), a selective 5-HT3 receptor agonist, can induce vomiting. However, downstream signaling pathways for the induced emesis remain unknown. The 5-HT3R channel has high permeability to extracellular calcium (Ca(2+)) and upon stimulation allows
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