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M1195

Metolazone

Name: Metolazone
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide

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About This Item

Empirical Formula (Hill Notation):

C₁₆H₁₆ClN₃O₃S

CAS Number:

17560-51-9

Molecular Weight:

365.83

NACRES:

NA.77

PubChem Substance ID:

24724532

UNSPSC Code:

12352200

EC Number:

241-539-3

MDL number:

MFCD00069304

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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Properties

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: >5 mg/mL

SMILES string

CC1Nc2cc(Cl)c(cc2C(=O)N1c3ccccc3C)S(N)(=O)=O

InChI

1S/C16H16ClN3O3S/c1-9-5-3-4-6-14(9)20-10(2)19-13-8-12(17)15(24(18,22)23)7-11(13)16(20)21/h3-8,10,19H,1-2H3,(H2,18,22,23)

InChI key

AQCHWTWZEMGIFD-UHFFFAOYSA-N

Gene Information

human ... SLC12A1(6557), SLC12A3(6559)

Description

Biochem/physiol Actions

Inhibitor of thiazide-sensitive Na⁺-Cl^- cotransporter; antihypertensive; moderate "loop" diuretic.

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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number

0000496627

0000438056

0000438055

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Articles

Sodium Channels

Voltage-gated sodium channels are present in most excitable cell membranes and play an important role in generating action potentials.

钠通道

电压门控钠通道存在于大多数可兴奋细胞膜中，在产生动作电位方面起着重要作用。

A single residue in transmembrane domain 11 defines the different affinity for thiazides between the mammalian and flounder NaCl transporters.

María Castañeda-Bueno et al.

American journal of physiology. Renal physiology, 299(5), F1111-F1119 (2010-08-20)

Little is known about the residues that control the binding and affinity of thiazide-type diuretics for their protein target, the renal Na(+)-Cl(-) cotransporter (NCC). Previous studies from our group have shown that affinity for thiazides is higher in rat (rNCC)

Determination of metolazone in human blood by liquid chromatography with electrospray ionization tandem mass spectrometry.

Guangli Wei et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 845(1), 169-173 (2006-08-16)

A rapid, sensitive and accurate liquid chromatographic-tandem mass spectrometric method is described for the determination of metolazone in human blood. Metolazone was extracted from blood using ethyl acetate and separated on a C18 column interfaced with a triple quadrupole tandem

Combination therapy with metolazone and loop diuretics in outpatients with refractory heart failure: an observational study and review of the literature.

Jens Rosenberg et al.

Cardiovascular drugs and therapy, 19(4), 301-306 (2005-09-29)

Metolazone is a potent thiazide-like diuretic. It is recommended in severe congestive heart failure (HF). We conducted a review of the existing literature and found that the available information on the use of metolazone in HF is based on studies

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Global Trade Item Number

SKU	GTIN
M1195-25MG	04061832574837
M1195-5MG	04061834037996