M1508
4-Methylumbelliferone sodium salt
fluorogenic, ≥98% (HPLC), crystalline
Synonym(s):
β-Methylumbelliferone, 7-Hydroxy-4-methylcoumarin
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About This Item
Linear Formula:
C10H7O3Na
CAS Number:
Molecular Weight:
198.15
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352204
EC Number:
227-790-1
MDL number:
Product Name
4-Methylumbelliferone sodium salt, ≥98% (HPLC), crystalline
Quality Level
assay
≥98% (HPLC)
form
crystalline
color
yellow
solubility
water: 50 mg/mL
SMILES string
[Na+].CC1=CC(=O)Oc2cc([O-])ccc12
InChI
1S/C10H8O3.Na/c1-6-4-10(12)13-9-5-7(11)2-3-8(6)9;/h2-5,11H,1H3;/q;+1/p-1
InChI key
JGMQHDNPUCPRQE-UHFFFAOYSA-M
General description
4-methylumbelliferone (4-MU) is a coumarin derivative.
Application
4-Methylumbelliferone sodium salt has been used:
- as a substrate to analyze the enzyme kinetics of its glucuronidation in the human liver
- as a standard to quantify the free 4-methylumbelliferone released as a result of enzyme-substrate action
- in cell survival assay to inhibit hyaluronan (HA) production and to study its effect on chemoresistance in ovarian cancer
Biochem/physiol Actions
4-methylumbelliferone (4-MU) serves as a hyaluronan (HA) synthesis blocker. It exhibits anti-inflammatory, anti-fibrogenic, and antitumor properties. 4-MU is used to treat biliary spasms and might also be beneficial in nonalcoholic steatohepatitis (NASH), inflammation, hepatocyte injury, and fibrotic response. 4-MU is known to be glucuronidated by most of the uridine 5ฺ-diphospho-glucuronosyltransferase (UGT) isoforms of the human liver. This makes it a potent probe substrate to examine the overall hepatic UGTs activity.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Ai-Sheng Xiong et al.
PloS one, 6(11), e26773-e26773 (2011-11-19)
A β-glucuronidase variant, GUS-TR3337, that was obtained by directed evolution exhibited higher thermostability than the wild-type enzyme, GUS-WT. In this study, the utility of GUS-TR337 as an improved reporter was evaluated. The corresponding gus-tr3337 and gus-wt genes were independently cloned
Gale E Smith et al.
Virology, 509, 90-97 (2017-06-19)
Avian influenza A (H5N1) viruses represent a growing threat for an influenza pandemic. The presence of widespread avian influenza virus infections further emphasizes the need for vaccine strategies for control of pre-pandemic H5N1 and other avian influenza subtypes. Influenza neuraminidase
Matías A Pibuel et al.
Glycobiology, 31(1), 29-43 (2020-05-31)
Glioblastoma (GBM), the most frequent primary tumor of the central nervous system, has a median survival of 14.6 months. 4-Methylumbelliferone (4MU) is a coumarin derivative widely used as a hyaluronan synthesis inhibitor with proven antitumor activity and without toxic effects reported.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| M1508-100G | 04061832909073 |
| M1508-10G | 04061834040767 |
| M1508-25G | 04061834040774 |