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Merck
CN

M1544

Sigma-Aldrich

Resorufin methyl ether

Synonym(s):

7-Methoxy-3H-phenoxazin-3-one, Methoxyresorufin, O7-Methylresorufin

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About This Item

Empirical Formula (Hill Notation):
C13H9NO3
CAS Number:
5725-89-3
Molecular Weight:
227.22
Beilstein:
209529
MDL number:
MFCD00037663
UNSPSC Code:
12161501
PubChem Substance ID:
24896665
NACRES:
NA.47

Key Documents

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Assay

≥98.0% (HPLC)

Quality Level

200

form

powder

mp

≥220 °C (lit.)

solubility

dichloromethane: 0.95-1.05 mg/mL, clear, orange to very deep orange

storage temp.

2-8°C

SMILES string

COc1ccc2N=C3C=CC(=O)C=C3Oc2c1

InChI

1S/C13H9NO3/c1-16-9-3-5-11-13(7-9)17-12-6-8(15)2-4-10(12)14-11/h2-7H,1H3

InChI key

KNYYMGDYROYBRE-UHFFFAOYSA-N

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Application

Resorufin methyl ether have been used as substrate in the incubation mixture, during the determination of cytochrome P4501A activities such as ethoxyresorufin O-deethylase (EROD) and methoxyresorufin O-demethylase(MROD) in liver microsomes, using high performance liquid chromatography(HPLC).

Biochem/physiol Actions

Fluorimetric substrate for cytochrome P450 linked enzymes.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
124M4041V
018M4075V
068M4091V
13140615
0000111536

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Dissecting the insecticide-resistance- associated cytochrome P450 gene Cyp6g1.
McCart C and ffrench-Constant R H
Pest Management Science, 64(6), 639-645 (2008)
Caroline McCart et al.
Pest management science, 64(6), 639-645 (2008-03-14)
The cytochrome P450 gene Cyp6g1 is overtranscribed in all field isolates of DDT-resistant Drosophila melanogaster (Meigen) and confers a fitness advantage when inherited via the female. Overtranscription is associated with the insertion of an Accord transposable element into the 5'
Determination of cytochrome P450 1A activities in mammalian liver microsomes by high-performance liquid chromatography with fluorescence detection
Hanioka N, et al.
Journal of Chromatography. B, Biomedical Sciences and Applications, 744(2), 399-406 (2000)
Yune-Fang Ueng et al.
The Journal of pharmacy and pharmacology, 57(2), 227-232 (2005-02-22)
Rutaecarpine is a main active alkaloid present in the medicinal herb, Evodia rutaecarpa. The cytochrome P450 (CYP) 1A2 substrate, theophylline, is an important therapeutic agent for the treatment of asthma, but has a narrow therapeutic index. To evaluate the pharmacokinetic
M Teresa Donato et al.
Drug metabolism and disposition: the biological fate of chemicals, 34(9), 1556-1562 (2006-06-10)
Liver grafts discarded for transplantation because of macrosteatosis can constitute a valuable source of human hepatocytes for in vitro metabolic and pharmacotoxicological studies or for therapeutic applications. A condition for using hepatocyte suspensions for these purposes is the preservation of
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Articles

Phase I Drug Metabolism

Phase I biotransformation reactions increase drug compound polarity, mainly occurring in hepatic circulation.

一期药物代谢

一期生物转化反应在药物上引入或暴露官能团，目的是增加化合物的极性。尽管一期药物代谢发生在大多数组织中，但代谢的主要和首过部位发生在肝循环期间。

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