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Merck
CN

M1555

MAHMA NONOate

Synonym(s):

6-(2-Hydroxy-1-methyl-2-nitrosohydrazino)-N-methyl-1-hexanamine, NOC-9

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About This Item

Empirical Formula (Hill Notation):
C8H20N4O2
CAS Number:
146724-86-9
Molecular Weight:
204.27
NACRES:
NA.25
PubChem Substance ID:
24896668
UNSPSC Code:
12352106
MDL number:
MFCD01310509

Key Documents

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InChI

1S/C8H19N4O2/c1-9-7-5-3-4-6-8-11(2)12(14)10-13/h9H,3-8H2,1-2H3/q-1/p+1

SMILES string

[H][N+]([H])(C)CCCCCCN(C)N([O-])N=O

InChI key

WASRCWNCCFPNEJ-UHFFFAOYSA-O

shipped in

dry ice

storage temp.

−70°C

Quality Level

200

Application

NO donor

Biochem/physiol Actions

NO release: t1/2 = 3 min (phosphate buffer at 22° C)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000500199
0000500199
0000500198
0000500198
0000497923

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Zhao Zhong Chong et al.
Current neurovascular research, 2(3), 197-211 (2005-09-27)
Metabotropic glutamate receptors (mGluRs) are expressed throughout the mammalian central nervous system and integrate a host of signal transduction pathways that determine cellular function, plasticity and injury. Yet, one of the more unique regulatory functions of this family of GTP-binding
Mauricio Di Fulvio et al.
American journal of physiology. Heart and circulatory physiology, 284(5), H1686-H1692 (2003-01-11)
Nitric oxide (NO) donors regulate KCl cotransport (KCC) activity and cotransporter-1 and -3 (KCC1 and KCC3) mRNA expression in sheep erythrocytes and in primary cultures of rat vascular smooth muscle cells (VSMCs), respectively. In this study, we used NONOates as
A M Vincent et al.
Journal of neurobiology, 40(2), 171-184 (1999-07-21)
Neuronal injury is intricately linked to the activation of three distinct neuronal endonucleases. Since these endonucleases are exquisitely pH dependent, we investigated in primary rat hippocampal neurons the role of intracellular pH (pH(i)) regulation during nitric oxide (NO)-induced toxicity. Neuronal
J F Leikert et al.
FEBS letters, 506(2), 131-134 (2001-10-10)
4,5-Diaminofluorescein (DAF-2) and its membrane-permeable derivate DAF-2 diacetate are fluorescent probes that have been developed to perform real-time biological detection of nitric oxide (NO). Their use for intracellular imaging, however, has recently been seriously questioned and data using DAF-2 for
Francis A Sylvester et al.
American journal of physiology. Heart and circulatory physiology, 283(1), H353-H363 (2002-06-14)
Rats were fed a low-salt (LS; 0.4% NaCl) or high-salt (HS; 4.0% NaCl) diet for 3 days, and the responses of isolated cerebral arteries to acetylcholine (ACh), the nitric oxide (NO)-dependent dilator bradykinin, and the NO donor 6-(2-hydroxy-1-methyl-2-nitrosohydrazino)-N-methyl-1-hex-anamine (NOC-9) were
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Articles

Sensor Dyes

Nitric oxide (NO) as a signal transporter in neurons, endothelial cells and in the immune system.

感应染料

一氧化氮 (NO) 是神经元、内皮细胞和免疫系统中的信号转运分子。

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