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M1555

MAHMA NONOate

Name: MAHMA NONOate
Brand: SIGMA

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Synonym(s):

6-(2-Hydroxy-1-methyl-2-nitrosohydrazino)-N-methyl-1-hexanamine, NOC-9

Empirical Formula (Hill Notation):

C₈H₂₀N₄O₂

CAS Number:

146724-86-9

Molecular Weight:

204.27

MDL number:

MFCD01310509

PubChem Substance ID:

24896668

NACRES:

NA.25

Quality Level

200

shipped in

dry ice

storage temp.

−70°C

SMILES string

[H][N+]([H])(C)CCCCCCN(C)N([O-])N=O

InChI

1S/C8H19N4O2/c1-9-7-5-3-4-6-8-11(2)12(14)10-13/h9H,3-8H2,1-2H3/q-1/p+1

InChI key

WASRCWNCCFPNEJ-UHFFFAOYSA-O

Application

NO donor

Biochem/physiol Actions

NO release: t_1/2 = 3 min (phosphate buffer at 22° C)

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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mGluRI targets microglial activation and selectively prevents neuronal cell engulfment through Akt and caspase dependent pathways.

Zhao Zhong Chong et al.

Current neurovascular research, 2(3), 197-211 (2005-09-27)

Metabotropic glutamate receptors (mGluRs) are expressed throughout the mammalian central nervous system and integrate a host of signal transduction pathways that determine cellular function, plasticity and injury. Yet, one of the more unique regulatory functions of this family of GTP-binding

Reliable in vitro measurement of nitric oxide released from endothelial cells using low concentrations of the fluorescent probe 4,5-diaminofluorescein.

J F Leikert et al.

FEBS letters, 506(2), 131-134 (2001-10-10)

4,5-Diaminofluorescein (DAF-2) and its membrane-permeable derivate DAF-2 diacetate are fluorescent probes that have been developed to perform real-time biological detection of nitric oxide (NO). Their use for intracellular imaging, however, has recently been seriously questioned and data using DAF-2 for

NONOates regulate KCl cotransporter-1 and -3 mRNA expression in vascular smooth muscle cells.

Mauricio Di Fulvio et al.

American journal of physiology. Heart and circulatory physiology, 284(5), H1686-H1692 (2003-01-11)

Nitric oxide (NO) donors regulate KCl cotransport (KCC) activity and cotransporter-1 and -3 (KCC1 and KCC3) mRNA expression in sheep erythrocytes and in primary cultures of rat vascular smooth muscle cells (VSMCs), respectively. In this study, we used NONOates as

Nitric oxide donors enhance calcitonin gene-related peptide-induced elevations of cyclic AMP in vascular smooth muscle cells.

L F Lu et al.

European journal of pharmacology, 376(3), 307-314 (1999-08-17)

Vasorelaxant effects of calcitonin gene-related peptide (CGRP) are dependent on endothelium-derived nitric oxide (NO) in some arteries. The mechanism involved is still not clear. In the present study, we used NO donors (sodium nitroprusside (SNP) and 6-(2-hydroxy-1-methyl-2-nitrisohydrazino)-N-methyl-1-hyxanamine (NOC-9)), cyclic GMP

High-salt diet depresses acetylcholine reactivity proximal to NOS activation in cerebral arteries.

Francis A Sylvester et al.

American journal of physiology. Heart and circulatory physiology, 283(1), H353-H363 (2002-06-14)

Rats were fed a low-salt (LS; 0.4% NaCl) or high-salt (HS; 4.0% NaCl) diet for 3 days, and the responses of isolated cerebral arteries to acetylcholine (ACh), the nitric oxide (NO)-dependent dilator bradykinin, and the NO donor 6-(2-hydroxy-1-methyl-2-nitrosohydrazino)-N-methyl-1-hex-anamine (NOC-9) were

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