M1574
Miglitol
Synonym(s):
1-(2-Hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
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About This Item
Empirical Formula (Hill Notation):
C8H17NO5
CAS Number:
Molecular Weight:
207.22
UNSPSC Code:
12352205
EC Number:
276-661-6
NACRES:
NA.25
SMILES string
N1([C@@H]([C@H]([C@@H]([C@H](C1)O)O)O)CO)CCO
InChI key
IBAQFPQHRJAVAV-ULAWRXDQSA-N
InChI
1S/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,1-4H2/t5-,6+,7-,8-/m1/s1
biological source
synthetic (organic)
assay
≥98% (HPLC)
form
powder
mp
142-147 °C
solubility
water: 5 mg/mL, clear, colorless to faintly yellow
storage temp.
room temp
Quality Level
Related Categories
General description
Miglitol is an alpha-glucosidase inhibitor used as a glucose-lowering drug in diabetes research.
Storage Class
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Kazuki Mochizuki et al.
Bioscience, biotechnology, and biochemistry, 74(12), 2470-2474 (2010-12-15)
β(2) integrins (CD11s/CD18) promote the attachment of leukocytes to vascular endothelial cells. We performed in this study sucrose loading to rats with moderate postprandial hyperglycemia with/without once-daily dosing of the α-glucosidase inhibitor, miglitol, for 4 days under 4-h fasting conditions.
Sheng-Hwu Hsieh et al.
Acta diabetologica, 48(1), 71-77 (2010-10-22)
The objective of this study is to examine the efficacy and tolerability of miglitol with respect to improving glycemic control in Chinese patients with type 2 diabetes mellitus inadequately controlled by diet and sulfonylurea treatment. This was a randomized, double-blinded
Kazutaka Aoki et al.
Acta diabetologica, 49(3), 225-230 (2011-09-08)
We recently reported that the administration of miglitol alone just before breakfast improved postprandial hyperglycemia and increased active glucagon-like peptide-1 (GLP-1) levels after lunch in men without diabetes. Miglitol and dipeptidyl peptidase-4 inhibitors, such as sitagliptin, enhance plasma active GLP-1
Kyra Jones et al.
Bioorganic & medicinal chemistry, 19(13), 3929-3934 (2011-06-15)
Inhibition of intestinal α-glucosidases and pancreatic α-amylases is an approach to controlling blood glucose and serum insulin levels in individuals with Type II diabetes. The two human intestinal glucosidases are maltase-glucoamylase and sucrase-isomaltase. Each incorporates two family 31 glycoside hydrolases
Kenichi Matsuura et al.
Diabetes technology & therapeutics, 14(5), 423-429 (2012-02-10)
We compared the effects of miglitol as an add-on to bolus insulin and dose-intensified bolus insulin on postprandial glycemic excursions by continuous glucose monitoring (CGM). The glucose levels of 21 type 2 diabetes patients admitted for glycemic control were monitored
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