M1684
(2S,3S,4S)-2-Methyl-2-(carboxycyclopropyl)glycine
Synonym(s):
(2S,3S,4S)-MCCG
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About This Item
Empirical Formula (Hill Notation):
C7H11NO4
CAS Number:
Molecular Weight:
173.17
MDL number:
UNSPSC Code:
12352200
solubility
H2O: >10 mg/mL
storage temp.
−20°C
SMILES string
C[C@](N)([C@H]1C[C@@H]1C(O)=O)C(O)=O
Biochem/physiol Actions
Potent antagonist at mGluR2 metabotropic glutamate receptors
Analysis Note
Stereochemistry confirmed by x-ray crystallography
Regulatory Information
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P J Attwell et al.
Brain research, 805(1-2), 138-143 (1998-09-12)
The anticonvulsant effects of intracerebral administration of the highly potent group II metabotropic glutamate receptor agonist, DCG-IV, were tested in fully kindled rats following daily electrical stimulation of the basolateral amygdala. The agonist caused a dose-dependent increase in the generalized
T Knöpfel et al.
Neuropharmacology, 34(8), 1099-1102 (1995-08-01)
The two reported metabotropic glutamate receptor (mGluR) antagonists, alpha-methyl-cyclopropyl glycine (MCCG) and alpha-methyl-aminophosphonobutyrate (MAP4) were tested on the mGluR1b, mGluR2 and mGluR4a subtypes of human mGluRs. Neither MCCG (500 microM) nor MAP4 (500 microM) antagonized the activation of mGluR1b by
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