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Merck
CN

M1809

MRS 1523

>98% (HPLC)

Synonym(s):

3-Propyl-6-ethyl-5-[(ethylthio)carbonyl]-2 phenyl-4-propyl-3-pyridine carboxylate

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About This Item

Empirical Formula (Hill Notation):
C23H29NO3S
CAS Number:
212329-37-8
Molecular Weight:
399.55
NACRES:
NA.77
PubChem Substance ID:
24278127
UNSPSC Code:
12352200
MDL number:
MFCD03787977

Key Documents

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Product Name

MRS 1523, >98% (HPLC)

InChI

1S/C23H29NO3S/c1-5-12-17-19(23(26)28-8-4)18(7-3)24-21(16-13-10-9-11-14-16)20(17)22(25)27-15-6-2/h9-11,13-14H,5-8,12,15H2,1-4H3

SMILES string

CCCOC(=O)c1c(CCC)c(C(=O)SCC)c(CC)nc1-c2ccccc2

InChI key

UUSHFEVEROROSP-UHFFFAOYSA-N

assay

>98% (HPLC)

form

oil

color

colorless to light brown

solubility

DMSO: >10 mg/mL
H2O: insoluble

shipped in

wet ice

storage temp.

2-8°C

Quality Level

100

Gene Information

human ... ADORA3(140)
rat ... Adora1(29290), Adora2a(25369), Adora3(25370)

Application

MRS 1523 has been used as an inhibitor of adenosine receptors in SW1990 and BxPC3 pancreatic cancer cells, LX2 human hepatic stellate cells and human coronary smooth muscle cells.

Biochem/physiol Actions

MRS 1523 is a selective adenosine A3 receptor antagonist in the rat.

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

Sold under license from the National Institutes of Health

wgk

WGK 3

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

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Certificates of Analysis (COA)

Lot/Batch Number
0000401926
0000401926
0000236135
0000236135
0000150346

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A H Li et al.
Journal of medicinal chemistry, 41(17), 3186-3201 (1998-08-14)
The structure-activity relationships of 6-phenyl-1,4-dihydropyridine derivatives as selective antagonists at human A3 adenosine receptors have been explored (Jiang et al. J. Med. Chem. 1997, 39, 4667-4675). In the present study, related pyridine derivatives have been synthesized and tested for affinity
C H Mitchell et al.
The American journal of physiology, 276(3 Pt 1), C659-C666 (1999-03-10)
Adenosine stimulates Cl- channels of the nonpigmented (NPE) cells of the ciliary epithelium. We sought to identify the specific adenosine receptors mediating this action. Cl- channel activity in immortalized human (HCE) NPE cells was determined by monitoring cell volume in
Elena Lucarini et al.
Pain, 161(9), 2179-2190 (2020-05-08)
Pharmacological tools for chronic visceral pain management are still limited and inadequate. A3 adenosine receptor (A3AR) agonists are effective in different models of persistent pain. Recently, their activity has been related to the block of N-type voltage-gated Ca2+ channels (Cav2.2)
The A3 adenosine receptor agonist, namodenoson, ameliorates non-alcoholic steatohepatitis in mice
Fishman P, et al.
International Journal of Molecular Medicine, 44(6), 2256-2264 (2019)
Shira Cohen et al.
Journal of immunology research, 2018, 2310970-2310970 (2018-06-05)
Interleukin-17 and interleukin-23 play major roles in the inflammatory process in psoriasis. The Gi protein-associated A3 adenosine receptor (A3AR) is known to be overexpressed in inflammatory cells and in peripheral blood mononuclear cells (PBMCs) of patients with autoimmune inflammatory conditions.
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