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M2319

Mefloquine hydrochloride

Name: Mefloquine hydrochloride
Brand: SIGMA

≥98% (HPLC), Cx36 and Cx50 blocker, powder

Synonym(s):

(AS)-rel-a-(2R)-2-Piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol monohydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₇ClF₆N₂O

CAS Number:

51773-92-3

Molecular Weight:

414.77

NACRES:

NA.77

PubChem Substance ID:

24724536

UNSPSC Code:

12352202

EC Number:

257-412-0

MDL number:

MFCD00797519

Assay:

≥98% (HPLC)

Form:

powder

Storage condition:

desiccated

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Properties

Product Name

Mefloquine hydrochloride, ≥98% (HPLC), powder

Quality Segment

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

DMSO: soluble 38 mg/mL, H₂O: insoluble

SMILES string

Cl[H].[H][C@@]1(CCCCN1)[C@@H](O)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F

InChI

1S/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/m1./s1

InChI key

WESWYMRNZNDGBX-YLCXCWDSSA-N

Description

Application

Mefloquine hydrochloride has been used:

to treat cochlear organotypic cultures with various doses to evaluate its role in cellular pathway involved in apoptosis
in screening for in vitro antischistosomal activity
in cytotoxicity assay of glioblastoma cells

Biochem/physiol Actions

Mefloquine is broadly used as an antimalarial drug. It inhibits 80S ribosomes of Plasmodium. It has numerous side effects like anxiety, dizziness, tremor, headache, and hearing loss. Mefloquine damages cochlear and vestibular hair cells through apoptosis. It also damages spiral ganglion neurons, degenerates cortical neuron and disrupts neuronal calcium homeostasis.

Blocker of gap junction channels Cx36 and Cx50.

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pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

0000294579

0000196117

0000134876

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Global Trade Item Number

SKU	GTIN
M2319-100MG	04061834041894