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M2378

Mucin from porcine stomach

Type II

Synonym(s):

MUC

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About This Item

CAS Number:
84082-64-4
UNSPSC Code:
12352202
EC Number:
282-010-7
NACRES:
NA.61
MDL number:
MFCD00131629
Form:
powder
Biological source:
Porcine stomach
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biological source

Porcine stomach

Quality Segment

200

type

Type II

form

powder

composition

bound sialic acid, ≤1.2%

technique(s)

cell culture | mammalian: suitable

solubility

1 M NaOH: soluble 20 mg/mL

UniProt accession no.

A0A5G2QSD1

storage temp.

2-8°C

Gene Information

pig ... MUC2(100127145)

General description

Mucin is majorly composed of carbohydrate units, crucial for structural architecture and conformation. The monomer of mucin is 640 kDa, with protein contributing to only 20% of the molecular weight. The carbohydrate component is attached to the threonine and serine side chains. Mucins are classified into secreted and transmembrane mucins.
Mucins or mucus glycoproteins are the main macromolecular components of mammalian mucus. It was also used in a study to evaluate the sputum smears concentrated by cyto-centrifugation for detection of acid-fast bacilli.

Application

Mucin from porcine stomach has been used:
  • in the standard curve generation for quantifying mucin-2 generated during mucosal inflammation in mice
  • as a component of digestion fluid solutions in in vitro human digestion model
  • as a component of simulated saliva fluid

Mucin from porcine stomach was used in studies on the binding site of the galactose-specific agglutinin PA-IL from Pseudomonas aeruginosa.

Biochem/physiol Actions

Mucin has wide pharmacological applications in drug delivery. Mucins play a protective role in inflammation. Deregulation in mucin synthesis contributes to tumorigenesis and chronic inflammation.
Mucus forms the protective cover for all epithelial surfaces. The major structural component of mucus is gel-forming mucins. The mucus layer covering the intestinal epithelium has the MUC2 mucin as its central molecule. MUC2 is produced by goblet cells.

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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