M2449
MB-3
≥95% (HPLC), Gcn5 HAT inhibitor, powder
Synonym(s):
γ-butyrolactone, Butyrolactone 3, (2R,3S)-rel-4-Methylene-5-oxo-2-propyltetrahydrofuran-3-carboxylic acid
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About This Item
Empirical Formula (Hill Notation):
C9H12O4
Molecular Weight:
184.19
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
powder
Product Name
MB-3, ≥95% (HPLC)
Quality Segment
assay
≥95% (HPLC)
form
powder
color
white to off-white
solubility
H2O: ≥10 mg/mL, DMSO: ≥20 mg/mL
storage temp.
−20°C
SMILES string
CCC[C@H]1OC(=O)C(=C)[C@@H]1C(O)=O
InChI
1S/C9H12O4/c1-3-4-6-7(8(10)11)5(2)9(12)13-6/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7+/m1/s1
InChI key
SRQUTZJZABSZRQ-RQJHMYQMSA-N
Application
MB-3 has been used as a general control non-repressible 5 (GCN5) inhibitor:
- to study its effects on lamin A/C-associated pY19-Cav-2-mediated histone H3 acetylations
- to analyze its effects on the growth of Arabidopsis thaliana seedlings
- to study its effects on craniofacial chondrocyte maturation
Biochem/physiol Actions
MB-3 can modify the gene expression in murine embryonic stem cells as well as yeast. It hinders the acetyltransferase activity of general control non-repressible 5 (GCN5) by binding to acetyl CoA pocket present in GCN5.
MB-3 is a Gcn5 HAT (Histone Acetyltransferase) inhibitor; anti-inflammatory, anti-carcinogenic.
Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
Storage Class
11 - Combustible Solids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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