M258
MARC from mouse
>97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture
Synonym(s):
MCP-3
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About This Item
UNSPSC Code:
51111800
MDL number:
biological source
mouse
recombinant
expressed in E. coli
assay
>97% (SDS-PAGE)
form
lyophilized powder
potency
0.1-0.3 μg/mL ED50
mol wt
Mw ~8.5 kDa
storage condition
avoid repeated freeze/thaw cycles (Storage in "frost-free" freezers is not recommended)
technique(s)
cell culture | mammalian: suitable
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Ccl7(20306)
Biochem/physiol Actions
MARC, a member of the β (CC) chemokine family of inflammatory and immunoregulatory cytokines, is a monocyte and T lymphocyte chemoattractant. MARC may be the mouse homolog of the human MCP-3 (monocyte chemotactic protein 3) gene.
MARC, a member of the β (CC) chemokine family of inflammatory and immunoregulatory cytokines, is a monocyte and T lymphocyte chemoattractant. MARC may be the mouse homolog of the human MCP-3 (monocyte chemotactic protein 3) gene. MARC/MCP-3 expression has also been detected during murine experimental allergic encephalomyelitis in the spinal cord and in LPS-stimulated murine WEHI -3 cells and Swiss 3T3 cells where MARC expression is glucocorticoid-attenuated. Mouse CCR-2 binds JE/MCP-1 with high affinity and MARC/MCP-3 with lower affinity.
Member of the β (CC) chemokine family of inflammatory and immunoregulatory cytokines; a monocyte and T lymphocyte chemoattractant; may be the mouse homolog of the human MCP-3 (monocyte chemotactic protein 3) gene.
Physical form
Lyophilized from a 0.2 μm filtered solution in 30% acetonitrile and 0.1% trifluoroacetic acid containing 0.5 mg bovine serum albumin.
Analysis Note
The biological activity is measured by its ability to chemoattract 2-day cultured human monocytes.
Regulatory Information
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P A Kulmburg et al.
The Journal of experimental medicine, 176(6), 1773-1778 (1992-12-01)
In an attempt to characterize genes participating in the allergic late phase reaction, we have isolated a novel intercrine/chemokine (called MARC) from a cDNA library of the stimulated mouse mast cell line, CPII. As measured by Northern blotting, it is
T Kurihara et al.
The Journal of biological chemistry, 271(20), 11603-11607 (1996-05-17)
The C-C chemokines human monocyte chemoattractant protein-1 and -3 (MCP-1 and MCP-3) and mouse JE and FIC are potent activators of monocytes. Several receptors for MCP-1 and MCP-3 have been cloned from human monocytic cell lines, and one of these
K Matsushima et al.
The Journal of experimental medicine, 169(4), 1485-1490 (1989-04-01)
A novel basic heparin-binding monocyte chemotactic factor (MCF) was purified to homogeneity from the conditioned media of human myelomonocytic cell line THP-1 based on its in vitro monocyte chemotactic activity. The purified MCF was homogenous and estimated to be 15
S Thirion et al.
Biochemical and biophysical research communications, 201(2), 493-499 (1994-06-15)
When the mouse macrophage cell line WEHI-3 is triggered with LPS it produces proteases and secondary cytokines including interleukin-6 and chemokines. In an attempt to isolate the mouse homologue of the human monocyte chemotactic protein-3 (MCP-3), a cDNA library from
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