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M2672

(±)-α-Methyl-(4-tetrazolylphenyl)glycine

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About This Item

Empirical Formula (Hill Notation):
C10H11N5O2
CAS Number:
169209-66-9
Molecular Weight:
233.23
UNSPSC Code:
12352202
PubChem Substance ID:
329817948
MDL number:
MFCD00672653
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form

solid

storage temp.

2-8°C

SMILES string

CC(N)(C(O)=O)c1ccc(cc1)-n2cnnn2

InChI

1S/C10H11N5O2/c1-10(11,9(16)17)7-2-4-8(5-3-7)15-6-12-13-14-15/h2-6H,11H2,1H3,(H,16,17)

InChI key

PUQSGMIEFYCTSW-UHFFFAOYSA-N

Biochem/physiol Actions

(±)-α-Methyl-(4-tetrazolylphenyl)glycine (MTPG) was used in rat models of cerebral ischemia to explore the role of group II metabotropic glutamate receptors mGluR2/3 in brain ischemia tolerance. MTPG inhibited the induction of ischemia tolerance indicating the involvement of mGluR2/3 in the induction of the protective mechanism.
Potent antagonist for (1S,3S)-ACPD-sensitive receptors; preference for GluR2 and GluR3 subtypes

Storage Class

13 - Non Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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