M2689
Methyl γ-linolenyl fluorophosphonate
≥98%, methyl acetate solution
Synonym(s):
(6Z,9Z,12Z)-Octadecatrienyl-phosphonofluoridic acid
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About This Item
Empirical Formula (Hill Notation):
C19H34FO2P
Molecular Weight:
344.44
UNSPSC Code:
41106300
EC Number:
201-185-2
NACRES:
NA.77
MDL number:
Product Name
Methyl γ-linolenyl fluorophosphonate, ≥98%, methyl acetate solution
assay
≥98%
form
methyl acetate solution
shipped in
dry ice
storage temp.
−70°C
Quality Level
Related Categories
Biochem/physiol Actions
An analog of MAFP which has been widely studied as an inhibitor of phospholipases, FAAH, and as a cannabinoid receptor ligand.
Preparation Note
To change the solvent, simply evaporate the methyl acetate under a gentle stream of nitrogen and immediately add the solvent of choice.
supp_hazards
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
target_organs
Central nervous system
Storage Class
3 - Flammable liquids
wgk
WGK 2
flash_point_f
3.2 °F - closed cup
flash_point_c
-16 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Regulatory Information
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Philippe J Nadeau et al.
Molecular biology of the cell, 20(16), 3628-3637 (2009-07-03)
ASK1 cysteine oxidation allows JNK activation upon oxidative stress. Trx1 negatively regulates this pathway by reducing the oxidized cysteines of ASK1. However, precisely how oxidized ASK1 is involved in JNK activation and how Trx1 regulates ASK1 oxidoreduction remains elusive. Here
Salimata Bagayoko et al.
PLoS pathogens, 17(9), e1009927-e1009927 (2021-09-14)
Regulated cell necrosis supports immune and anti-infectious strategies of the body; however, dysregulation of these processes drives pathological organ damage. Pseudomonas aeruginosa expresses a phospholipase, ExoU that triggers pathological host cell necrosis through a poorly characterized pathway. Here, we investigated
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