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M2901

Molsidomine

Name: Molsidomine
Brand: SIGMA

Synonym(s):

N-(Ethoxycarbonyl)-3-(4-morpholino)sydnone imine, SIN-10

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About This Item

Empirical Formula (Hill Notation):

C₉H₁₄N₄O₄

CAS Number:

25717-80-0

Molecular Weight:

242.23

NACRES:

NA.77

PubChem Substance ID:

24278544

UNSPSC Code:

12352200

EC Number:

247-207-4

MDL number:

MFCD00869301

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Properties

storage temp.

2-8°C

SMILES string

CCOC(=O)N=C1O[N-][N+](=C1)N2CCOCC2

InChI

1S/C9H14N4O4/c1-2-16-9(14)10-8-7-13(11-17-8)12-3-5-15-6-4-12/h7H,2-6H2,1H3/b10-8-

InChI key

XLFWDASMENKTKL-NTMALXAHSA-N

Description

Application

Molsidomine has been used as nitric oxide (NO)-releasing vasodilator to study the effect of NO on angiostatin production in aging rat kidneys.

Biochem/physiol Actions

Molsidomine is an effective vasodilator and a long-lasting nitric oxide (NO) donor. It is a pro-drug that is enzymatically decarboxylated to form 3-morpholinosydnone imine (SIN-1) in the liver. Molsidomine is used as an anti-anginal agent and possesses antioxidant properties. It may be used to treat cisplatin-induced oxidative stress in the liver tissue. Molsidomine has also been used during angina pectoris, heart failure, and after myocardial infarction.

Orally active, long acting vasodilator; antianginal; converted by the liver to the active metabolite, SIN-1

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Pictograms

GHS07

Signal Word

Warning

Hazard Codes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

WGK

WGK 3

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves

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