M3172
Mitogen activated protein kinase from rat
≥95% (SDS-PAGE), buffered aqueous glycerol solution, recombinant, expressed in E. coli (N-terminal histidine tagged)
Synonym(s):
ERK2, Extracellular-signal regulated kinase, MAP Kinase Activated from rat, MAPK
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About This Item
UNSPSC Code:
12352200
MDL number:
recombinant
expressed in E. coli (N-terminal histidine tagged)
assay
≥95% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
≥500 U/mg
mol wt
42 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
rat ... Mapk1(116590)
Biochem/physiol Actions
MAP kinase is a serine/threonine kinase that is activated by MEK through a phosphorylation cascade. The cascade starts with extracellular signals transmitted by growth factor-regulated receptor tyrosine kinases or G-protein coupled receptors. Dually phosphorylated (Thr and Tyr) MAP kinase translocates from the cytoplasm to the nucleus, where it phosphorylates protein transcription factors, transducing extracellular signals into genomic responses, proliferation or differentiation.
MAP kinase is a serine/threonine kinase that is activated by MEK through a phosphorylation cascade.
Physical form
Solution in 20 mM Tris, pH 7.5, 150 mM NaCl, 1 mM EGTA, 10% glycerol, 1 mM DTT, and 0.03% Brij®.
Other Notes
One unit of activated MAP kinase will transfer 1 nmole of phosphate from ATP to myelin basic protein per min at 30 °C.
Legal Information
Brij is a registered trademark of Croda International PLC
Storage Class
12 - Non Combustible Liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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