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Merck
CN

M3189

Mepivacaine hydrochloride

98.0-102.0%, meets USP testing specifications

Synonym(s):

1-Methyl-2′,6′-pipecoloxylidine hydrochloride, N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C15H22N2O · HCl
CAS Number:
1722-62-9
Molecular Weight:
282.81
EC Number:
217-023-9
MDL number:
MFCD00144738
UNSPSC Code:
12352200
PubChem Substance ID:
57654370

Key Documents

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Agency

meets USP testing specifications

Assay

98.0-102.0%

originator

Novocol

SMILES string

CN1CCCCC1C(NC2=C(C)C=CC=C2C)=O.Cl

InChI

1S/C15H22N2O.ClH/c1-11-7-6-8-12(2)14(11)16-15(18)13-9-4-5-10-17(13)3;/h6-8,13H,4-5,9-10H2,1-3H3,(H,16,18);1H

InChI key

RETIMRUQNCDCQB-UHFFFAOYSA-N

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

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Biochem/physiol Actions

Local anesthetic. Reversibly blocks transient Na+ inward current, as well as the steady-state K+ outward current.
Local anesthetic. Reversibly blocks transient Na+ inward current, as well as the steady-state K+ outward current. Blocks tandem pore (TASK) and Kv1.5, potassium channels in model systems.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novocol. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301,H336

Hazard Classifications

Acute Tox. 3 Oral - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBK4373V
SLBG7495V
SLBC9892V
081M1441V
120M1861V

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Hui-Jin Sung et al.
Canadian journal of physiology and pharmacology, 90(7), 863-872 (2012-06-19)
Mepivacaine is an aminoamide-linked local anesthetic with an intermediate duration that intrinsically produces vasoconstriction both in vivo and in vitro. The aims of this in-vitro study were to examine the direct effect of mepivacaine in isolated rat aortic rings and
Mi Hyeon Lee et al.
Pain medicine (Malden, Mass.), 13(11), 1381-1388 (2012-09-28)
Compared with the blind technique, ultrasound-guided stellate ganglion block (SGB) reduces the amount of local anesthetic needed for a successful block. The purpose of this study is to determine the minimal, optimal volume of local anesthetic required for successful ultrasound-guided
Jeff Gadsden et al.
Anesthesia and analgesia, 115(4), 963-967 (2012-07-17)
During peripheral nerve blockade, different local anesthetics may be sequentially administered. Typically, a short- or intermediate-acting local anesthetic is administered before a long-acting local anesthetic to achieve a block with rapid onset and long duration. However, there is a paucity
D Van Vynckt et al.
Veterinary and comparative orthopaedics and traumatology : V.C.O.T, 25(4), 307-313 (2012-06-15)
Assessment of the effect of intra-articular anaesthesia on lameness caused by medial coronoid disease. This study included 90 dogs that were evaluated for the complaint of unilateral forelimb lameness. All dogs were suspected of having an elbow problem for which
Kaoru Hara et al.
Regional anesthesia and pain medicine, 37(3), 289-293 (2012-04-06)
The present study was conducted to determine the incidence of unintentional intraneural injection during ultrasound-guided subgluteal sciatic nerve block using a low-frequency transducer. We also observed the effects of intraneural injection using ropivacaine and mepivacaine. Enrolled in the study were
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Chromatograms

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