M3281
α-Methyl-DL-tyrosine methyl ester hydrochloride
≥95% (HPLC)
Synonym(s):
α-MT methyl ester hydrochloride, 2-Methyl-4-hydroxy-DL-phenylalanine methyl ester hydrochloride, AMPT methyl ester hydrochloride
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About This Item
Linear Formula:
4-(HO)C6H4CH2C(CH3)(NH2)CO2CH3 · HCl
CAS Number:
Molecular Weight:
245.70
UNSPSC Code:
12352108
NACRES:
NA.32
PubChem Substance ID:
EC Number:
230-900-0
Beilstein/REAXYS Number:
5163031
MDL number:
Quality Level
assay
≥95% (HPLC)
mp
192 °C (dec.) (lit.)
solubility
DMSO: ≥20 mg/mL, clear, colorless to faintly yellow
storage temp.
−20°C
SMILES string
Cl[H].COC(=O)C(C)(N)Cc1ccc(O)cc1
InChI
1S/C11H15NO3.ClH/c1-11(12,10(14)15-2)7-8-3-5-9(13)6-4-8;/h3-6,13H,7,12H2,1-2H3;1H
InChI key
OOVDEPZODSXAMU-UHFFFAOYSA-N
Gene Information
human ... TH(7054)
Application
α-Methyl-DL-tyrosine methyl ester hydrochloride has been used to evaluate norepinephrine turnover.
Biochem/physiol Actions
α-Methyl-DL-tyrosine (α-MT) prevents hyperactivity, sniffing-licking-gnawing syndrome, anorexia and ameliorates certain effects of amphetamine. It inhibits dopamine production and prevents apoptosis stimulated by mutant α-synuclein.
Tyrosine hydroxylase inhibitor.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Antiamphetamine effects following inhibition of tyrosine hydroxylase
Weissman A
Journal of Pharmacology and Experimental Therapeutics, 151(3), 339-352 (1966)
Central sympathetic innervations to visceral and subcutaneous white adipose tissue
Nguyen, Ngoc Ly T and Randall, Jessica and Banfield, Bruce W and Bartness, Timoth NLT, et al.
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 306(6), R375-R386 (2014)
Dopamine-dependent neurotoxicity of alpha-synuclein: a mechanism for selective neurodegeneration in Parkinson disease
Xu J, et al.
Nature Medicine, 8(6), 600-600 (2002)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| M3281-1G | 04061834050087 |
| M3281-5G | 04061833428535 |