M3655
D-Mannose 6-phosphate sodium salt
≥98% (HPLC)
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About This Item
Linear Formula:
C6H12O9PNa
CAS Number:
Molecular Weight:
282.12
MDL number:
UNSPSC Code:
12352201
PubChem Substance ID:
NACRES:
NA.25
biological source
synthetic (inorganic)
Quality Level
Assay
≥98% (HPLC)
form
powder
technique(s)
HPLC: suitable
impurities
<12% water (Karl Fischer)
color
white
solubility
water: 50 mg/mL, clear to cloudy, colorless
cation traces
Na: 7.3-9.0% (anhydrous)
storage temp.
2-8°C
SMILES string
[Na].OC(COP(O)(O)=O)C(O)C(O)C(O)C=O
InChI
1S/C6H13O9P.Na.H/c7-1-3(8)5(10)6(11)4(9)2-15-16(12,13)14;;/h1,3-6,8-11H,2H2,(H2,12,13,14);;
InChI key
RUFPTDNHMAGVMV-UHFFFAOYSA-N
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General description
Mannose is a monosaccharide.
Application
Mannose has been used in a study to assess in vivo targeting of alveolar macrophages. It has also been used in a study to investigate genetic engineering of the phosphocarrier protein NPr.
Biochem/physiol Actions
Mannose-6-Pis a molecule bound by lectin in the immune system. It is converted to fructose 6-phosphate by mannose phosphate isomerase and is a key targeting signal for acid hydrolase precursor proteins that are transported to lysosomes.
Other Notes
To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
涉药品监管产品
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Yossef Lopez-de Los Santos et al.
The Journal of biological chemistry, 287(35), 29931-29939 (2012-07-07)
The Escherichia coli phosphoenolpyruvate:sugar phosphotransferase system (PTS) in prokaryotes mediates the uptake and phosphorylation of its numerous substrates through a phosphoryl transfer chain where a phosphoryl transfer protein, HPr, transfers its phosphoryl group to any of several sugar-specific Enzyme IIA
Petra Tiels et al.
Nature biotechnology, 30(12), 1225-1231 (2012-11-20)
Lysosomal storage diseases are treated with human lysosomal enzymes produced in mammalian cells. Such enzyme therapeutics contain relatively low levels of mannose-6-phosphate, which is required to target them to the lysosomes of patient cells. Here we describe a method for
Wei Cheong Ngeow et al.
Journal of anatomy, 219(5), 638-645 (2011-08-05)
Microsurgical repair of transected peripheral nerves is compromised by the formation of scar tissue and the development of a neuroma, thereby limiting the success of regeneration. The aim of this study was to quantify histomorphometrically the structural changes in neural
Alberto Ramírez-Mata et al.
Experimental cell research, 317(16), 2364-2373 (2011-06-16)
Endocytosis and transport of bovine liver β-glucuronidase to lysosomes in human fibroblasts are mediated by two receptors: the well-characterized cation-independent mannose 6-phosphate receptor (IGF-II/Man6PR) and an IGF-II/Man6PR-independent receptor, which recognizes a Ser-Trp*-Ser sequence present on the ligand. The latter receptor
Maria Francisca Coutinho et al.
Molecular genetics and metabolism, 105(4), 542-550 (2012-01-24)
Lysosomal hydrolases are synthesized in the rough endoplasmic reticulum and specifically transported through the Golgi apparatus to the trans-Golgi network, from which transport vesicles bud to deliver them to the endosomal/lysosomal compartment. The explanation of how are the lysosomal enzymes
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