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Merck
CN

M3781

6α-Methylprednisolone 21-hemisuccinate sodium salt

synthetic, ≥98.00% (TLC), Prednisolone derivative, lyophilized powder

Synonym(s):

6α-Methylprednisolone sodium succinate, MPSL, 6α-Methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-hemisuccinate

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About This Item

Linear Formula:
C26H33O8Na
CAS Number:
2375-03-3
Molecular Weight:
496.53
NACRES:
NA.77
PubChem Substance ID:
24896873
UNSPSC Code:
51111800
EC Number:
219-156-8
MDL number:
MFCD00152612

Key Documents

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Product Name

6α-Methylprednisolone 21-hemisuccinate sodium salt, lyophilized powder

InChI

1S/C26H34O8.Na/c1-14-10-16-17-7-9-26(33,20(29)13-34-22(32)5-4-21(30)31)25(17,3)12-19(28)23(16)24(2)8-6-15(27)11-18(14)24;/h6,8,11,14,16-17,19,23,28,33H,4-5,7,9-10,12-13H2,1-3H3,(H,30,31);/q;+1/p-1/t14-,16-,17-,19-,23+,24-,25-,26-;/m0./s1

InChI key

FQISKWAFAHGMGT-SGJOWKDISA-M

SMILES string

[Na+].C[C@H]1CC2C3CC[C@](O)(C(=O)COC(=O)CCC([O-])=O)[C@@]3(C)C[C@H](O)C2[C@@]4(C)C=CC(=O)C=C14

biological source

synthetic

sterility

non-sterile

assay

≥98.00% (TLC)

form

lyophilized powder

technique(s)

toxicology assay: suitable

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

room temp

Quality Level

100

Gene Information

human ... NR3C1(2908)

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Application

6α-methylprednisolone 21-hemisuccinate sodium salt has been used to investigate glucocorticoid-induced osteonecrosis under hypoxic conditions in the MC3T3-E1 osteoblast cell line using a cell cytotoxicity assay, flow cytometry and western blotting.

Biochem/physiol Actions

Glucocorticoid with slightly longer half-life than that of prednisolone.

Physical form

Lyophilized containing ~5% phosphate buffer salts.

pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H351,H360

Hazard Classifications

Carc. 2 - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN5669
BCCG3096
BCBZ8796
BCBW7102
SLBG7439V

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Julio Urrutia et al.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association, 16(4), 439-442 (2011-04-30)
The effect of corticosteroids on spinal fusion healing has not yet been determined. To evaluate the effect of corticosteroids on lumbar spinal fusion we designed a randomized, placebo-controlled animal study using high-dose methylprednisolone sodium succinate, which is widely used in
Acute liver failure and aplastic anemia in an 11-year-old girl.
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Archives of dermatology, 147(10), 1227-1228 (2011-10-19)
Takaaki Kitakawa et al.
Documenta ophthalmologica. Advances in ophthalmology, 124(3), 249-254 (2012-03-10)
The purpose of this study was to report a patient with acute zonal occult outer retinopathy (AZOOR) unilaterally, who received steroid pulse therapy. A 42-year-old woman presented with photopsias and severe vision loss in her left eye. Visual acuity was
Basilar leptomeningitis in Vogt-Koyanagi-Harada disease.
Yince Loh
Neurology, 78(6), 438-439 (2012-02-09)
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