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M3781

6α-Methylprednisolone 21-hemisuccinate sodium salt

Name: 6&#945;-Methylprednisolone 21-hemisuccinate sodium salt
Brand: SIGMA

synthetic, ≥98.00% (TLC), Prednisolone derivative, lyophilized powder

Synonym(s):

6α-Methylprednisolone sodium succinate, MPSL, 6α-Methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-hemisuccinate

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About This Item

Linear Formula:

C₂₆H₃₃O₈Na

CAS Number:

2375-03-3

Molecular Weight:

496.53

NACRES:

NA.77

PubChem Substance ID:

24896873

UNSPSC Code:

51111800

EC Number:

219-156-8

MDL number:

MFCD00152612

Assay:

≥98.00% (TLC)

Form:

lyophilized powder

Quality level:

100

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Properties

Product Name

6α-Methylprednisolone 21-hemisuccinate sodium salt, lyophilized powder

biological source

synthetic

Quality Level

100

sterility

non-sterile

assay

≥98.00% (TLC)

form

lyophilized powder

technique(s)

toxicology assay: suitable

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

[Na+].C[C@H]1CC2C3CC[C@](O)(C(=O)COC(=O)CCC([O-])=O)[C@@]3(C)C[C@H](O)C2[C@@]4(C)C=CC(=O)C=C14

InChI

1S/C26H34O8.Na/c1-14-10-16-17-7-9-26(33,20(29)13-34-22(32)5-4-21(30)31)25(17,3)12-19(28)23(16)24(2)8-6-15(27)11-18(14)24;/h6,8,11,14,16-17,19,23,28,33H,4-5,7,9-10,12-13H2,1-3H3,(H,30,31);/q;+1/p-1/t14-,16-,17-,19-,23+,24-,25-,26-;/m0./s1

InChI key

FQISKWAFAHGMGT-SGJOWKDISA-M

Gene Information

human ... NR3C1(2908)

Description

Application

6α-methylprednisolone 21-hemisuccinate sodium salt has been used to investigate glucocorticoid-induced osteonecrosis under hypoxic conditions in the MC3T3-E1 osteoblast cell line using a cell cytotoxicity assay, flow cytometry and western blotting.

Biochem/physiol Actions

Glucocorticoid with slightly longer half-life than that of prednisolone.

Physical form

Lyophilized containing ~5% phosphate buffer salts.

pictograms

GHS08

signalword

Danger

hcodes

H351,H360

pcodes

P201 - P308 + P313

Hazard Classifications

Carc. 2 - Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Regulatory Information

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Angioedema in a 47-year-old woman with hypocomplementemic urticarial vasculitis syndrome.

Julie M Jones et al.

The Journal of the American Osteopathic Association, 112(2), 90-92 (2012-02-15)

Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a type III hypersensitivity reaction characterized by urticaria with persistent acquired hypocomplementemia. Although HUVS is uncommon, it is important for physicians to be familiar with this disease, as the initial presentation is often life-threatening

Dapsone hypersensitivity syndrome complicated by Scedosporium apiospermum pneumonia in an immunocompetent patient.

L Ceccarelli et al.

Infection, 40(4), 459-462 (2011-11-30)

[The issue of methylprednisolone sodium succinate dosage for use].

Yu-cai Zhang et al.

Zhonghua er ke za zhi = Chinese journal of pediatrics, 49(5), 389-390 (2011-06-01)

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Global Trade Item Number

SKU	GTIN
M3781-250MG	04061832850801
M3781-1G	04061826236765
M3781-25MG	04061832850818