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M3808

MRS 2179 ammonium salt hydrate

≥98% (HPLC)

Synonym(s):

2′-Deoxy-N6-methyl adenosine 3′,5′-diphosphate diammonium salt

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About This Item

Empirical Formula (Hill Notation):
C11H17N5O9P2 · xNH3 · yH2O
CAS Number:
101204-49-3
Molecular Weight:
425.23 (anhydrous free acid basis)
UNSPSC Code:
12352200
PubChem Substance ID:
24278551
NACRES:
NA.77
Assay:
≥98% (HPLC)
Quality level:
100
Storage condition:
desiccated
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Quality Level

100

assay

≥98% (HPLC)

storage condition

desiccated

solubility

DMSO: 1.1 mg/mL, H2O: >10 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

N.O.CNc1ncnc2n(cnc12)[C@H]3C[C@H](OP(O)(O)=O)[C@@H](COP(O)(O)=O)O3

InChI

1S/C11H17N5O9P2.H3N.H2O/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6(25-27(20,21)22)7(24-8)3-23-26(17,18)19;;/h4-8H,2-3H2,1H3,(H,12,13,14)(H2,17,18,19)(H2,20,21,22);1H3;1H2/t6-,7+,8+;;/m0../s1

InChI key

DEQIORFOBOEGKZ-ZJWYQBPBSA-N

Gene Information

human ... P2RY1(5028)

Application

MRS 2179 ammonium salt hydrate has been used as a P2Y1 receptor antagonist in porcine coronary small arteries, endothelial cells, and hippocampal astrocytes.

Biochem/physiol Actions

Competitive P2Y1 purinoceptor antagonist.
MRS 2179 resists localized venous thrombosis and is useful in treating thrombotic syndromes due to its platelet aggregation inhibition functionality.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000217941
0000217941
0000120364
0000120363
0000109113

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A Baurand et al.
European journal of pharmacology, 412(3), 213-221 (2001-02-13)
The effects of a potent P2Y1 receptor antagonist, N6-methyl-2'-deoxyadenosine-3',5'-bisphosphate (MRS2179) on adenosine-5'-diphosphate (ADP)-induced platelet aggregation in vitro, ex vivo and on the bleeding time in vivo were determined. In suspensions of washed platelets, MRS2179 inhibited ADP-induced platelet shape change, aggregation
Clara Cavelier et al.
Arteriosclerosis, thrombosis, and vascular biology, 32(1), 131-139 (2011-10-08)
Both HDLs and their major protein constituent apolipoprotein A-I (apoA-I) are transported through aortic endothelial cells. The knock-down of the ATP-binding cassette transporters A1 (ABCA1), G1 (ABCG1), and of the scavenger receptor-BI (SR-BI) diminishes but does not completely block the
Anthony Baurand et al.
Cardiovascular drug reviews, 21(1), 67-76 (2003-02-22)
MRS-2179 is a selective P2Y(1) receptor antagonist, a strong inhibitor of ADP-induced platelet aggregation in vitro and ex vivo. By i.v. administration to mice MRS-2179 increases resistance to thromboembolism induced by a mixture of collagen and epinephrine or by a
Nobuhiro Moro et al.
Experimental and therapeutic medicine, 21(6), 575-575 (2021-04-15)
The aim of the current study was to determine effects of mild traumatic brain injury (TBI), with or without blockade of purinergic ATP Y1 (P2Y1) receptors or store-operated calcium channels, on extracellular levels of ATP, glutamate, glucose and lactate. Concentrations
Zhichao Zhou et al.
Purinergic signalling, 13(3), 319-329 (2017-05-26)
We previously demonstrated that uridine adenosine tetraphosphate (Up4A) induces potent and partially endothelium-dependent relaxation in the healthy porcine coronary microvasculature. We subsequently showed that Up4A-induced porcine coronary relaxation was impaired via downregulation of P1 receptors after myocardial infarction. In view
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Global Trade Item Number

SKUGTIN
M3808-25MG04061832091938
M3808-5MG04061832091945

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