M3824
α-Mangostin
≥98% (HPLC)
Synonym(s):
α-MG, alpha-Mangostin
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About This Item
Empirical Formula (Hill Notation):
C24H26O6
CAS Number:
Molecular Weight:
410.46
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352212
EC Number:
448-420-7
MDL number:
Quality Segment
assay
≥98% (HPLC)
form
powder
solubility
methanol: 1 mg/mL, clear, very light yellow
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
SMILES string
COc1c(O)cc2Oc3cc(O)c(C\C=C(\C)C)c(O)c3C(=O)c2c1C\C=C(/C)C
InChI
1S/C24H26O6/c1-12(2)6-8-14-16(25)10-19-21(22(14)27)23(28)20-15(9-7-13(3)4)24(29-5)17(26)11-18(20)30-19/h6-7,10-11,25-27H,8-9H2,1-5H3
InChI key
GNRIZKKCNOBBMO-UHFFFAOYSA-N
General description
α-Mangostin (α-MG) is the most abundant phytochemical derived from the pericarp of Garcinia mangostana L.. It is a tetraoxygenated diprenylated xanthone. The chemical structure of α-MG molecule is 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methyl-2-butenyl)- 9H-xanthen-9-one.
Application
α-Mangostin has been used:
- to study its protective effect against oxidative stress mediated-retinal cell death
- to study its role as an antigenotoxic agent in DNA protection against oxidative damage
- to understand its anti-bacterial activity against Staphylococcus epidermidis RP62A
Biochem/physiol Actions
α-Mangostin displays various pharmacological properties both in in vitro and in vivo studies. These include antimicrobial, anticarcinogenic, antidiabetic, neuroprotective, hepatoprotective and anti-inflammatory properties.
Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory.
Xanthone derivative isolated from mangosteen (Garcinia mangostana). Antioxidant and anti-inflammatory. α-mangostin has been shown to induce apoptosis via the mitochondrial pathway, reduce cell proliferation and inhibit tumorigenesis.
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
flash_point_f
Not applicable
flash_point_c
Not applicable
Storage Class
11 - Combustible Solids
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