M4004
N2-Methylguanosine
~95%
Synonym(s):
m2G
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About This Item
Empirical Formula (Hill Notation):
C11H15N5O5
CAS Number:
Molecular Weight:
297.27
UNSPSC Code:
41106305
PubChem Substance ID:
MDL number:
assay
~95%
form
solid
storage temp.
−20°C
SMILES string
CNC1=NC(=O)c2ncn(C3OC(CO)C(O)C3O)c2N1
InChI
1S/C11H15N5O5/c1-12-11-14-8-5(9(20)15-11)13-3-16(8)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15,20)
InChI key
SLEHROROQDYRAW-UHFFFAOYSA-N
Application
N2-Methylguanosine (m2is used to characterize and study the metabolism of naturally occurring methylated guanosine in RNAs.
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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H A Heus et al.
European journal of biochemistry, 188(2), 275-281 (1990-03-10)
The 3'-terminal colicin fragments of 16S ribosomal RNA were isolated from Bacillus stearothermophilus and from its kasugamycin-resistant (ksgA) derivative lacking N6-dimethylation of the two adjacent adenosines in a hairpin loop. The fragment from the ksgA strain still contains a naturally
Sarah F Mitchell et al.
Molecular cell, 39(6), 950-962 (2010-09-25)
Translational control is frequently exerted at the stage of mRNA recruitment to the initiating ribosome. We have reconstituted mRNA recruitment to the 43S preinitiation complex (PIC) using purified S. cerevisiae components. We show that eIF3 and the eIF4 factors not
Quiping Cao et al.
RNA (New York, N.Y.), 16(1), 221-227 (2009-11-26)
Pumilio 2 (Pum2) interacts with the 3' UTR-containing pumilio binding element (PBE) of RINGO/SPY mRNA to repress translation in Xenopus oocytes. Here, we show that Pum2 also binds directly to the 5' 7mG cap structure; in so doing, it precludes
Victoria H Cowling
The Biochemical journal, 425(2), 295-302 (2009-12-23)
The 7-methylguanosine cap added to the 5' end of mRNA is essential for efficient gene expression and cell viability. Methylation of the guanosine cap is necessary for the translation of most cellular mRNAs in all eukaryotic organisms in which it
Hua-Yu Li et al.
Journal of mass spectrometry : JMS, 44(5), 641-651 (2009-01-15)
Urinary-modified nucleosides have a potential role as cancer biomarkers for a number of malignant diseases. High performance liquid chromatography (HPLC) was combined with full-scan mass spectrometry, MS/MS analysis and accurate mass measurements in order to identify purine nucleosides purified from
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